| Literature DB >> 23380990 |
Angelique P A Vermeiren1, Hans Bosma, Pieter-Jelle Visser, Maurice P Zeegers, Caroline Graff, Michael Ewers, Giovanni B Frisoni, Lutz Frölich, Harald Hampel, Roy W Jones, Patrick G Kehoe, Hermine Lenoir, Lennart Minthon, Flavio M Nobili, Marcel Olde Rikkert, Anne-Sophie Rigaud, Philip Scheltens, Hilkka Soininen, Luiza Spiru, Magda Tsolaki, Lars-Olof Wahlund, Bruno Vellas, Gordon Wilcock, Lyzel S Elias-Sonnenschein, Frans R J Verhey.
Abstract
We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.Entities:
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Year: 2013 PMID： 23380990 DOI： 10.3233/JAD-122182
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472