Literature DB >> 23380739

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells.

Kyoung-Ran Kim1, Da-Rae Kim, Taemin Lee, Ji Young Yhee, Byeong-Su Kim, Ick Chan Kwon, Dae-Ro Ahn.   

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

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Year:  2013        PMID： 23380739     DOI： 10.1039/c3cc38693g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  36 in total

Review 1.  DNA nanotechnology from the test tube to the cell.

Authors:  Yuan-Jyue Chen; Benjamin Groves; Richard A Muscat; Georg Seelig
Journal:  Nat Nanotechnol       Date:  2015-09       Impact factor: 39.213

2.  DNA nanostructures: a shift from assembly to applications.

Authors:  Laura A Lanier; Harry Bermudez
Journal:  Curr Opin Chem Eng       Date:  2015-02-01       Impact factor: 5.163

Review 3.  Engineering artificial machines from designable DNA materials for biomedical applications.

Authors:  Hao Qi; Guoyou Huang; Yulong Han; Xiaohui Zhang; Yuhui Li; Belinda Pingguan-Murphy; Tian Jian Lu; Feng Xu; Lin Wang
Journal:  Tissue Eng Part B Rev       Date:  2015-02-09       Impact factor: 6.389

4.  Modulation of chondrocyte motility by tetrahedral DNA nanostructures.

Authors:  Sirong Shi; Shiyu Lin; Xiaoru Shao; Qianshun Li; Zhang Tao; Yunfeng Lin
Journal:  Cell Prolif       Date:  2017-08-09       Impact factor: 6.831

Review 5.  Design and application of multifunctional DNA nanocarriers for therapeutic delivery.

Authors:  P Charoenphol; H Bermudez
Journal:  Acta Biomater       Date:  2013-07-27       Impact factor: 8.947

6.  A DNA-Device that Mediates Selective Endosomal Escape and Intracellular Delivery of Drugs and Biologicals.

Authors:  Silvia Muro
Journal:  Adv Funct Mater       Date:  2014-05-21       Impact factor: 18.808

7.  Design strategies for programmable oligonucleotide nanotherapeutics.

Authors:  Fitsum Feleke Sahle; Tao L Lowe
Journal:  Drug Discov Today       Date:  2019-09-13       Impact factor: 7.851

Review 8.  The Growing Development of DNA Nanostructures for Potential Healthcare-Related Applications.

Authors:  Divita Mathur; Igor L Medintz
Journal:  Adv Healthc Mater       Date:  2019-03-07       Impact factor: 11.092

9.  Chemical and Physical Characteristics of Doxorubicin Hydrochloride Drug-Doped Salmon DNA Thin Films.

Authors:  Bramaramba Gnapareddy; Sreekantha Reddy Dugasani; Taewoo Ha; Bjorn Paulson; Taehyun Hwang; Taesung Kim; Jae Hoon Kim; Kyunghwan Oh; Sung Ha Park
Journal:  Sci Rep       Date:  2015-07-31       Impact factor: 4.379

10.  Aptamer-targeted DNA nanostructures for therapeutic delivery.

Authors:  Phapanin Charoenphol; Harry Bermudez
Journal:  Mol Pharm       Date:  2014-04-17       Impact factor: 4.939
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