Literature DB >> 23379556

Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target.

N K Zenkov1, E B Menshchikova, V O Tkachev.   

Abstract

The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE system, key targets for pharmacological intervention, and interconnection of this system with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote "indirect" antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

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Year:  2013        PMID： 23379556     DOI： 10.1134/S0006297913010033

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  28 in total

1.  Melatonin Protects Methamphetamine-Induced Neuroinflammation Through NF-κB and Nrf2 Pathways in Glioma Cell Line.

Authors:  Pichaya Jumnongprakhon; Piyarat Govitrapong; Chainarong Tocharus; Decha Pinkaew; Jiraporn Tocharus
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2.  The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress.

Authors:  Karina S MacDowell; Javier R Caso; David Martín-Hernández; Beatriz M Moreno; José L M Madrigal; Juan A Micó; Juan C Leza; Borja García-Bueno
Journal:  Neurotherapeutics       Date:  2016-10       Impact factor: 7.620

Review 3.  Nrf2/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases.

Authors:  Artem P Gureev; Vasily N Popov
Journal:  Neurochem Res       Date:  2019-01-07       Impact factor: 3.996

Review 4.  RPE necroptosis in response to oxidative stress and in AMD.

Authors:  Jakub Hanus; Chastain Anderson; Shusheng Wang
Journal:  Ageing Res Rev       Date:  2015-09-11       Impact factor: 10.895

5.  Luteolin alleviates methylglyoxal-induced cytotoxicity in osteoblastic MC3T3-E1 cells.

Authors:  Kwang Sik Suh; Suk Chon; Eun Mi Choi
Journal:  Cytotechnology       Date:  2016-05-24       Impact factor: 2.058

6.  NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation.

Authors:  Vitor de Miranda Ramos; Alfeu Zanotto-Filho; Matheus Augusto de Bittencourt Pasquali; Karina Klafke; Juciano Gasparotto; Peter Dunkley; Daniel Pens Gelain; José Cláudio Fonseca Moreira
Journal:  Mol Neurobiol       Date:  2015-11-05       Impact factor: 5.590

Review 7.  Relationship between oxidative stress and nuclear factor-erythroid-2-related factor 2 signaling in diabetic cardiomyopathy (Review).

Authors:  Xia Wu; Leitao Huang; Jichun Liu
Journal:  Exp Ther Med       Date:  2021-04-25       Impact factor: 2.447

8.  Effect of the Lipid Peroxidation Product 4-Hydroxynonenal on Neuroinflammation in Microglial Cells: Protective Role of Quercetin and Monochloropivaloylquercetin.

Authors:  Ahmet Cumaoğlu; Aslı Özge Ağkaya; Zehra Özkul
Journal:  Turk J Pharm Sci       Date:  2018-12-31

9.  Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole.

Authors:  Yasunobu Yamashita; Takashi Ueyama; Toshio Nishi; Yuta Yamamoto; Akatsuki Kawakoshi; Shogo Sunami; Mikitaka Iguchi; Hideyuki Tamai; Kazuki Ueda; Takao Ito; Yoshihiro Tsuruo; Masao Ichinose
Journal:  PLoS One       Date:  2014-05-20       Impact factor: 3.240

Review 10.  The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders.

Authors:  Bifeng Gao; An Doan; Brooks M Hybertson
Journal:  Clin Pharmacol       Date:  2014-02-03
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