OBJECTIVE: The purpose of this study was to investigate a genetic moderation effect of dopamine receptor-4 gene (DRD4) alleles that have 7 or more repeats on the efficacy of a preventive intervention to deter rural African American adolescents' substance use. METHODS:Adolescents (N = 502, M age = 16 years) were assigned randomly to the Strong African American Families-Teen (SAAF-T) program or to a control condition and were followed for 22 months. Adolescents provided data on substance use, and both adolescents and their primary caregivers provided data on intervention-targeted protective parenting practices. RESULTS:Male adolescents who carried at least one allele of DRD4 with 7 or more repeats who were assigned to the control condition evinced more substance use across 22 months than did (a) carriers of at least one allele of DRD4 with 7 or more repeats who were assigned to SAAF-T or (b) adolescents assigned to either condition who carried two alleles of DRD4 with 6 or fewer repeats. These findings were mediated by DRD4 × SAAF-T interaction effects on increases in intervention-targeted protective parenting practices, a mediated moderation effect. CONCLUSIONS: The results imply that prevention effects on health-relevant outcomes for genetically susceptible individuals, such as carriers of at least one allele of DRD4 with 7 or more repeats, may be underestimated. PsycINFO Database Record (c) 2014 APA, all rights reserved.
RCT Entities:
OBJECTIVE: The purpose of this study was to investigate a genetic moderation effect of dopamine receptor-4 gene (DRD4) alleles that have 7 or more repeats on the efficacy of a preventive intervention to deter rural African American adolescents' substance use. METHODS: Adolescents (N = 502, M age = 16 years) were assigned randomly to the Strong African American Families-Teen (SAAF-T) program or to a control condition and were followed for 22 months. Adolescents provided data on substance use, and both adolescents and their primary caregivers provided data on intervention-targeted protective parenting practices. RESULTS: Male adolescents who carried at least one allele of DRD4 with 7 or more repeats who were assigned to the control condition evinced more substance use across 22 months than did (a) carriers of at least one allele of DRD4 with 7 or more repeats who were assigned to SAAF-T or (b) adolescents assigned to either condition who carried two alleles of DRD4 with 6 or fewer repeats. These findings were mediated by DRD4 × SAAF-T interaction effects on increases in intervention-targeted protective parenting practices, a mediated moderation effect. CONCLUSIONS: The results imply that prevention effects on health-relevant outcomes for genetically susceptible individuals, such as carriers of at least one allele of DRD4 with 7 or more repeats, may be underestimated. PsycINFO Database Record (c) 2014 APA, all rights reserved.
Authors: Robin R Milhausen; Richard Crosby; William L Yarber; Ralph J DiClemente; Gina M Wingood; Kele Ding Journal: Am J Health Behav Date: 2003 Jul-Aug
Authors: Gene H Brody; Yi-Fu Chen; Tianyi Yu; Steven R H Beach; Steven M Kogan; Ronald L Simons; Michael Windle; Robert A Philibert Journal: Dev Psychopathol Date: 2012-08
Authors: V Asghari; O Schoots; S van Kats; K Ohara; V Jovanovic; H C Guan; J R Bunzow; A Petronis; H H Van Tol Journal: Mol Pharmacol Date: 1994-08 Impact factor: 4.436
Authors: Michael A Russell; Gabriel L Schlomer; H Harrington Cleveland; Mark E Feinberg; Mark T Greenberg; Richard L Spoth; Cleve Redmond; David J Vandenbergh Journal: Prev Sci Date: 2018-01
Authors: Charlie Rioux; Natalie Castellanos-Ryan; Sophie Parent; Frank Vitaro; Richard E Tremblay; Jean R Séguin Journal: Dev Psychopathol Date: 2015-06-01
Authors: Neeru Goyal; Fazil Aliev; Shawn J Latendresse; Darlene A Kertes; John M Bolland; Gayle R Byck; Brian Mustanski; Jessica E Salvatore; Danielle M Dick Journal: Subst Abus Date: 2016 Jul-Sep Impact factor: 3.716
Authors: Elif Isbell; Courtney Stevens; Eric Pakulak; Amanda Hampton Wray; Theodore A Bell; Helen J Neville Journal: Proc Natl Acad Sci U S A Date: 2017-08-17 Impact factor: 11.205