Literature DB >> 23378593

Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors.

Sergio Daniel Catz1.   

Abstract

The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell-specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. This review focuses on the latest discoveries on the function of Rab27 GTPases and their effectors Munc13-4 and Slp1 in neutrophil function comparatively to their functions in other leukocytes.

Entities:  

Keywords:  Munc13-4; exocytosis, phagocytosis; inflammation; innate immunity; synaptotagmin-like protein

Mesh：

Substances：

Year:  2013        PMID： 23378593      PMCID： PMC3774847          DOI： 10.1189/jlb.1112600

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  89 in total

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5.  A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.

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Journal:  EMBO Rep       Date:  2002-04-18       Impact factor: 8.807

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Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

8.  Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.

Authors:  Taruho S Kuroda; Mitsunori Fukuda; Hiroyoshi Ariga; Katsuhiko Mikoshiba
Journal:  Biochem Biophys Res Commun       Date:  2002-05-10       Impact factor: 3.575

9.  Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.

Authors:  Mitsunori Fukuda
Journal:  J Biol Chem       Date:  2002-08-19       Impact factor: 5.157

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  18 in total

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Authors:  Patricia R Taylor; Sanhita Roy; Evan C Meszaros; Yan Sun; Scott J Howell; Charles J Malemud; Eric Pearlman
Journal:  J Leukoc Biol       Date:  2016-03-31       Impact factor: 4.962

4.  Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.

Authors:  Jennifer L Johnson; Jing He; Mahalakshmi Ramadass; Kersi Pestonjamasp; William B Kiosses; Jinzhong Zhang; Sergio D Catz
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Review 5.  Sorting it out: regulation of exosome loading.

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Authors:  Jing He; Jennifer L Johnson; Jlenia Monfregola; Mahalakshmi Ramadass; Kersi Pestonjamasp; Gennaro Napolitano; Jinzhong Zhang; Sergio D Catz
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8.  Rab27a deletion impairs the therapeutic potential of endothelial progenitor cells for myocardial infarction.

Authors:  Wenyi Zhou; Xuefei Zheng; Chuanfang Cheng; Guixian Guo; Yun Zhong; Weihua Liu; Kefeng Liu; Yanfang Chen; Shiming Liu; Shaojun Liu
Journal:  Mol Cell Biochem       Date:  2020-10-23       Impact factor: 3.396

Review 9.  Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment.

Authors:  An Hendrix; Olivier De Wever
Journal:  Int J Mol Sci       Date:  2013-05-10       Impact factor: 5.923

10.  Differential regulation of Rab GTPase expression in monocyte-derived dendritic cells upon lipopolysaccharide activation: a correlation to maturation-dependent functional properties.

Authors:  Axel Berg-Larsen; Ole J B Landsverk; Cinzia Progida; Tone F Gregers; Oddmund Bakke
Journal:  PLoS One       Date:  2013-09-05       Impact factor: 3.240
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