| Literature DB >> 23376640 |
Wei Xu1, Guo-Sheng Chen, Yun Shao, Xiao-Lin Li, Hai-Chen Xu, Hao Zhang, Guo-Qing Zhu, Yi-Chan Zhou, Xiao-Pu He, Wei-Hao Sun.
Abstract
Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-increased COX-2 expression and cell proliferation were effectively blocked by CCK2R antagonist and inhibitors of JAK2 and PI3K. In addition, knockdown of STAT3 expression significantly attenuated G17-induced PI3K/Akt activation, COX-2 expression, and cell proliferation. These results suggest that CCK2R-mediated COX-2 up-regulation via JAK2/STAT3/PI3K/Akt pathway is involved in the proliferative effect of G17 on human gastric cancer cells.Entities:
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Year: 2013 PMID： 23376640 DOI： 10.1016/j.canlet.2012.12.030
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679