OBJECTIVE: To investigate diagnostic test accuracy (DTA) of different tests for obstructive sleep apnea (OSA) compared to polysomnography (PSG) in children. METHODS: We performed a systematic review according to DTA criteria published by the Cochrane Collaboration. Studies that compared any possible diagnostic test with PSG for diagnosing OSA were considered. Study quality assessment was conducted in each selected study and DTA measures recalculated by hand whenever possible. Excellent DTA was defined as positive likelihood ratio (PLR) > 10 and negative likelihood ratio (NLR) < 0.1. RESULTS: We identified 1064 potentially relevant studies, of which 33 met inclusion criteria. Study quality was generally low; 5 studies fulfilled all quality criteria and 11 studies included >100 subjects. Included studies compared 40 different tests to PSG. Only 13 studies used the currently accepted definition for OSA (i.e., apnea hypopnea index ≥1). In these studies, PLR ranged from 1.017 to ∞, NLR from 0 to 1.089. Sleep lab-based polygraphy, urinary biomarkers, and rhinomanometry (one study each) showed excellent DTA. CONCLUSION: There is limited evidence concerning diagnostic alternatives to PSG for identifying OSA in children. However, polygraphy, urinary biomarkers, and rhinomanometry may be valid tests if their apparently high DTA is confirmed by subsequent studies.
OBJECTIVE: To investigate diagnostic test accuracy (DTA) of different tests for obstructive sleep apnea (OSA) compared to polysomnography (PSG) in children. METHODS: We performed a systematic review according to DTA criteria published by the Cochrane Collaboration. Studies that compared any possible diagnostic test with PSG for diagnosing OSA were considered. Study quality assessment was conducted in each selected study and DTA measures recalculated by hand whenever possible. Excellent DTA was defined as positive likelihood ratio (PLR) > 10 and negative likelihood ratio (NLR) < 0.1. RESULTS: We identified 1064 potentially relevant studies, of which 33 met inclusion criteria. Study quality was generally low; 5 studies fulfilled all quality criteria and 11 studies included >100 subjects. Included studies compared 40 different tests to PSG. Only 13 studies used the currently accepted definition for OSA (i.e., apnea hypopnea index ≥1). In these studies, PLR ranged from 1.017 to ∞, NLR from 0 to 1.089. Sleep lab-based polygraphy, urinary biomarkers, and rhinomanometry (one study each) showed excellent DTA. CONCLUSION: There is limited evidence concerning diagnostic alternatives to PSG for identifying OSA in children. However, polygraphy, urinary biomarkers, and rhinomanometry may be valid tests if their apparently high DTA is confirmed by subsequent studies.
Authors: Graziela De Luca Canto; Camila Pachêco-Pereira; Secil Aydinoz; Paul W Major; Carlos Flores-Mir; David Gozal Journal: Sleep Med Rev Date: 2014-11-28 Impact factor: 11.609
Authors: Daniel Álvarez; María L Alonso-Álvarez; Gonzalo C Gutiérrez-Tobal; Andrea Crespo; Leila Kheirandish-Gozal; Roberto Hornero; David Gozal; Joaquín Terán-Santos; Félix Del Campo Journal: J Clin Sleep Med Date: 2017-05-15 Impact factor: 4.062
Authors: Graziela De Luca Canto; Camila Pachêco-Pereira; Secil Aydinoz; Paul W Major; Carlos Flores-Mir; David Gozal Journal: J Clin Sleep Med Date: 2015-01-15 Impact factor: 4.062
Authors: Hans J Welkoborsky; Christina Rose-Diekmann; Anja Pähler Vor der Holte; Hagen Ott Journal: Eur Arch Otorhinolaryngol Date: 2022-01-18 Impact factor: 2.503
Authors: Robrecht J H Logjes; Joanna E MacLean; Noor W de Cort; Christian F Poets; Véronique Abadie; Koen F M Joosten; Cory M Resnick; Ivy K Trindade-Suedam; Carlton J Zdanski; Christopher R Forrest; Frea H Kruisinga; Roberto L Flores; Kelly N Evans; Corstiaan C Breugem Journal: J Clin Sleep Med Date: 2021-08-01 Impact factor: 4.324
Authors: Felipe Damiani; Gabriel Rada; Juan Cristóbal Gana; Pablo E Brockmann; Gigliola Alberti Journal: BMJ Open Date: 2016-09-02 Impact factor: 2.692