| Literature DB >> 23374334 |
Abstract
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.Year: 2013 PMID： 23374334 DOI： 10.1016/j.cell.2013.01.025
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582