Literature DB >> 23374333

Unlatched BAX pairs for death.

Heather M Lamb1, J Marie Hardwick.   

Abstract

Self-interacting BAX proteins permeabilize outer mitochondrial membranes to trigger apoptotic cell death. Czabotar et al. present two revealing structures of BAX dimers: one dimer has an activator BH3 helix bound into its canonical cleft, and the other dimer exposes a planar hydrophobic face potentially critical for membrane interactions.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23374333      PMCID： PMC3975071          DOI： 10.1016/j.cell.2013.01.018

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria.

Authors:  Damien Arnoult; Laura M Bartle; Anna Skaletskaya; Delphine Poncet; Naoufal Zamzami; Peter U Park; Juanita Sharpe; Richard J Youle; Victor S Goldmacher
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

2.  An anti-apoptotic viral protein that recruits Bax to mitochondria.

Authors:  Delphine Poncet; Nathanael Larochette; Anne-Laure Pauleau; Patricia Boya; Abdel-Ali Jalil; Pierre-Francois Cartron; Francois Vallette; Céline Schnebelen; Laura M Bartle; Anna Skaletskaya; David Boutolleau; Jean-Claude Martinou; Victor S Goldmacher; Guido Kroemer; Naoufal Zamzami
Journal:  J Biol Chem       Date:  2004-03-05       Impact factor: 5.157

3.  Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

Authors:  G Dewson; S Ma; P Frederick; C Hockings; I Tan; T Kratina; R M Kluck
Journal:  Cell Death Differ       Date:  2011-10-21       Impact factor: 15.828

4.  BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Authors:  Evripidis Gavathiotis; Denis E Reyna; Marguerite L Davis; Gregory H Bird; Loren D Walensky
Journal:  Mol Cell       Date:  2010-11-12       Impact factor: 17.970

5.  BCL-XL dimerization by three-dimensional domain swapping.

Authors:  Jason W O'Neill; Michael K Manion; Brendan Maguire; David M Hockenbery
Journal:  J Mol Biol       Date:  2005-12-01       Impact factor: 5.469

6.  Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.

Authors:  Junhe Ma; Frank Edlich; Guillermo A Bermejo; Kristi L Norris; Richard J Youle; Nico Tjandra
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-03       Impact factor: 11.205

7.  Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Authors:  Peter E Czabotar; Dana Westphal; Grant Dewson; Stephen Ma; Colin Hockings; W Douglas Fairlie; Erinna F Lee; Shenggen Yao; Adeline Y Robin; Brian J Smith; David C S Huang; Ruth M Kluck; Jerry M Adams; Peter M Colman
Journal:  Cell       Date:  2013-01-31       Impact factor: 41.582

8.  Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

Authors:  Gorka Basañez; Juanita C Sharpe; Jennifer Galanis; Teresa B Brandt; J Marie Hardwick; Joshua Zimmerberg
Journal:  J Biol Chem       Date:  2002-10-14       Impact factor: 5.157

9.  Evolution of Bcl-2 homology motifs: homology versus homoplasy.

Authors:  Abdel Aouacheria; Valentine Rech de Laval; Christophe Combet; J Marie Hardwick
Journal:  Trends Cell Biol       Date:  2012-11-27       Impact factor: 20.808

10.  BAX activation is initiated at a novel interaction site.

Authors:  Evripidis Gavathiotis; Motoshi Suzuki; Marguerite L Davis; Kenneth Pitter; Gregory H Bird; Samuel G Katz; Ho-Chou Tu; Hyungjin Kim; Emily H-Y Cheng; Nico Tjandra; Loren D Walensky
Journal:  Nature       Date:  2008-10-23       Impact factor: 49.962
  10 in total
  1 in total

1.  The functional domains for Bax∆2 aggregate-mediated caspase 8-dependent cell death.

Authors:  Adriana Mañas; Sheng Wang; Adam Nelson; Jiajun Li; Yu Zhao; Huaiyuan Zhang; Aislinn Davis; Bingqing Xie; Natalia Maltsev; Jialing Xiang
Journal:  Exp Cell Res       Date:  2017-08-12       Impact factor: 3.905
  1 in total

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