AIM: Three secondary metabolites of lichens - usnic acid, atranorin and fumarprotocetraric acid - were evaluated for their in vitro antibacterial and antibiofilm activities against three strains each of methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) from cystic fibrosis patients. MATERIALS & METHODS: Antibacterial activity was assessed by broth microdilution, while antibiofilm activity was evaluated by spectrophotometry or viable count. RESULTS: Usnic acid was significantly more active than atranorin against planktonic cells, while fumarprotocetraric acid exhibited no activity. Atranorin was the most effective in counteracting adhesion to polystyrene, although usnic acid was more active against MRSA. Usnic acid and atranorin showed comparable activity against biofilm formation, although atranorin was more active against MRSA. Usnic acid was significantly more active than atranorin against preformed biofilms. CONCLUSION: Secondary metabolites of lichens may be considered to be 'lead compounds' for the development of novel molecules for the treatment of S. aureus infections in cystic fibrosis patients.
AIM: Three secondary metabolites of lichens - usnic acid, atranorin and fumarprotocetraric acid - were evaluated for their in vitro antibacterial and antibiofilm activities against three strains each of methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) from cystic fibrosispatients. MATERIALS & METHODS: Antibacterial activity was assessed by broth microdilution, while antibiofilm activity was evaluated by spectrophotometry or viable count. RESULTS:Usnic acid was significantly more active than atranorin against planktonic cells, while fumarprotocetraric acid exhibited no activity. Atranorin was the most effective in counteracting adhesion to polystyrene, although usnic acid was more active against MRSA. Usnic acid and atranorin showed comparable activity against biofilm formation, although atranorin was more active against MRSA. Usnic acid was significantly more active than atranorin against preformed biofilms. CONCLUSION: Secondary metabolites of lichens may be considered to be 'lead compounds' for the development of novel molecules for the treatment of S. aureus infections in cystic fibrosispatients.
Authors: Marwa Kerboua; Monia Ali Ahmed; Nsevolo Samba; Radhia Aitfella-Lahlou; Lucia Silva; Juan F Boyero; Cesar Raposo; Jesus Miguel Lopez Rodilla Journal: Molecules Date: 2021-02-20 Impact factor: 4.411
Authors: Noura Aoussar; Fatima Ezzahra Laasri; Mohammed Bourhia; Nedeljko Manoljovic; Rajaa Ait Mhand; Naima Rhallabi; Riaz Ullah; Abdelaaty A Shahat; Omar M Noman; Fahd A Nasr; Omer M Almarfadi; Mohammed El Mzibri; Perica Vasiljević; Laila Benbacer; Fouad Mellouki Journal: Evid Based Complement Alternat Med Date: 2020-12-02 Impact factor: 2.629
Authors: G Ulrich-Merzenich; A Koptina; A Shcherbakova; A A Strömstedt; U Göransson; O Gnezdilov; A Turanov; D Boldbaatar; D Kochkin Journal: World J Microbiol Biotechnol Date: 2021-07-07 Impact factor: 3.312