PURPOSE: To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. METHODS: A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS: All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION: Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
PURPOSE: To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. METHODS: A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS: All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION:Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
Authors: Edson Yuzur Yasojima; Renan Kleber Costa Teixeira; Abdallah de Paula Houat; Felipe Lobato da Silva Costa; Vitor Nagai Yamaki; Denilson José Silva Feitosa-Junior; Carlos Augusto Moreira Silva; Marcus Vinicius Henriques Brito Journal: Arq Bras Cir Dig Date: 2015 Jul-Sep
Authors: Francisco Bruno Teixeira; Raíra de Brito Silva; Osmar Alves Lameira; Liana Preto Webber; Roberta Souza D'Almeida Couto; Manoela Domingues Martins; Rafael Rodrigues Lima Journal: BMC Complement Altern Med Date: 2017-06-14 Impact factor: 3.659
Authors: Denilson José Silva Feitosa; Luan Teles Ferreira de Carvalho; Ingrid Rodrigues de Oliveira Rocha; Camila Noura de Brito; Rodrigo Alencar Moreira; Charles Alberto Villacorta de Barros Journal: Int Braz J Urol Date: 2018 Mar-Apr Impact factor: 1.541
Authors: Paulo Vicente Dos Santos Filho; Rafael Silva Santos; Sydney Correia Leão; Ivisson Xavier Duarte; Sonia Oliveira Lima Journal: Acta Cir Bras Date: 2021-01-20 Impact factor: 1.388