Literature DB >> 23370197

Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents.

Khaled Abouzid Mohamed Abouzid1, Nadia Abdalla Khalil, Eman Mohamed Ahmed, Sawsan Abo-Bakr Zaitone.   

Abstract

A series of nicotinic acid derivatives structurally related to niflumic acid and certain pyridazine-containing compounds have been synthesized and characterized by analytical and spectral data. All compounds were screened for their potential analgesic and anti-inflammatory activities. The compounds which displayed analgesic and anti-inflammatory activities were tested for ulcerogenicity and screened for in vivo inhibition of certain inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2). Compounds 1c, 2a, 2b, and 5a have shown potent analgesic and anti-inflammatory activities.

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Year:  2013        PMID： 23370197     DOI： 10.1248/cpb.c12-00949

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  4 in total

1.  Biodegradable m-PEG/PCL Core-Shell Micelles: Preparation and Characterization as a Sustained Release Formulation for Curcumin.

Authors:  Hossein Danafar; Soodabeh Davaran; Kobra Rostamizadeh; Hadi Valizadeh; Mehrdad Hamidi
Journal:  Adv Pharm Bull       Date:  2014-12-31

2.  Syntheses and Antibiotic Evaluation of 2-{[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonyl}benzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues.

Authors:  Abdulrazaq Tukur; Isaac Asusheyi Bello; Neil Anthony Koorbanally; James Dama Habila
Journal:  Int J Med Chem       Date:  2016-02-14

3.  Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities.

Authors:  Maiy Y Jaballah; Rabah A T Serya; Nasser Saad; Sohair M Khojah; Marawan Ahmed; Khaled Barakat; Khaled A M Abouzid
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

4.  Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer.

Authors:  Bi-Lan Wang; Yong-mei Shen; Qiong-wen Zhang; Yu-li Li; Min Luo; Ze Liu; Yan Li; Zhi-yong Qian; Xiang Gao; Hua-shan Shi
Journal:  Int J Nanomedicine       Date:  2013-09-24
  4 in total

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