OBJECTIVES: Treatment regimen for families of children with cystic fibrosis (CF) is considerable, particularly when nebulised therapies for chronic Pseudomonas aeruginosa airway infection are prescribed. Adherence to these regimens is variable, particularly in adolescence. Previously, we reported children to be more adherent in evenings compared to mornings, suggesting an association with time-pressure. The aim of this study was to determine whether adherence would be better in adolescent patients at weekends and during school holidays when time-pressures may be less. STUDY DESIGN: 24 patients (14 male, median [range] age 13.9 [11.1-16.8] years) were enrolled from two regional paediatric CF centres in the United Kingdom. Data for a full scholastic year, were downloaded openly from a breath-activated data logging nebuliser (I-neb™). Adherence (% of doses taken÷expected number) was calculated during term-times, holidays, weekends and weekdays, for each patient. RESULTS: Large variations in adherence were seen between patients. However, adherence during term-time was significantly better than holidays (p<0.001). Weekday adherence was better than weekend adherence in term-time but not holidays. Interestingly, patients prescribed three daily treatments took on average 1.4 treatments/day, a similar number to those prescribed two daily treatments. CONCLUSION: Overall adherence to inhaled therapies was reasonable, but significantly reduced during holiday periods. This suggests a need for families to have not only time, but also structure in their daily routine to maintain optimal adherence to long-term therapies. It is important for CF teams to appreciate these factors when supporting families.
OBJECTIVES: Treatment regimen for families of children with cystic fibrosis (CF) is considerable, particularly when nebulised therapies for chronic Pseudomonas aeruginosa airway infection are prescribed. Adherence to these regimens is variable, particularly in adolescence. Previously, we reported children to be more adherent in evenings compared to mornings, suggesting an association with time-pressure. The aim of this study was to determine whether adherence would be better in adolescent patients at weekends and during school holidays when time-pressures may be less. STUDY DESIGN: 24 patients (14 male, median [range] age 13.9 [11.1-16.8] years) were enrolled from two regional paediatric CF centres in the United Kingdom. Data for a full scholastic year, were downloaded openly from a breath-activated data logging nebuliser (I-neb™). Adherence (% of doses taken÷expected number) was calculated during term-times, holidays, weekends and weekdays, for each patient. RESULTS: Large variations in adherence were seen between patients. However, adherence during term-time was significantly better than holidays (p<0.001). Weekday adherence was better than weekend adherence in term-time but not holidays. Interestingly, patients prescribed three daily treatments took on average 1.4 treatments/day, a similar number to those prescribed two daily treatments. CONCLUSION: Overall adherence to inhaled therapies was reasonable, but significantly reduced during holiday periods. This suggests a need for families to have not only time, but also structure in their daily routine to maintain optimal adherence to long-term therapies. It is important for CF teams to appreciate these factors when supporting families.
Authors: John E Pascoe; Hemant Sawnani; Oscar H Mayer; Keith McConnell; Joseph M McDonough; Cynthia White; Anne M Rutkowski; Raouf S Amin; Avani C Modi Journal: Pediatr Pulmonol Date: 2016-11-22
Authors: Christopher M Siracusa; Jamie Ryan; Lisa Burns; Yu Wang; Nanhua Zhang; John P Clancy; Dennis Drotar Journal: J Cyst Fibros Date: 2015-06-11 Impact factor: 5.482
Authors: Christina J Nicolais; Ruth Bernstein; Estefany Saez-Flores; Katherine A McLean; Kristin A Riekert; Alexandra L Quittner Journal: J Clin Psychol Med Settings Date: 2019-12
Authors: Daniel H Grossoehme; Rhonda D Szczesniak; LaCrecia L Britton; Christopher M Siracusa; Alexandra L Quittner; Barbara A Chini; Sophia M Dimitriou; Michael Seid Journal: Ann Am Thorac Soc Date: 2015-06
Authors: Robert W Morton; Heather E Elphick; Elaine Edwards; William J Daw; Noreen S West Journal: Patient Prefer Adherence Date: 2017-05-08 Impact factor: 2.711