PURPOSE: The purpose of this study is to examine the impact of hypernatremia acquired after intensive care unit (ICU) admission on mortality and length of stay (LOS). MATERIALS AND METHODS: Data for this observational study were collected from patients admitted between January 1, 2008, and September 30, 2010 to 344 ICUs in the eICU Research Institute. RESULTS: Of the 207702 eligible patients, 8896 (4.3%) developed hypernatremia (serum Na >149 mEq/L). Hospital mortality was 32% for patients with hypernatremia and 11% for patients without hypernatremia (P < .0001). Intensive care unit LOS was 13.7 ± 9.7 days for patients with hypernatremia and 5.1 ± 4.6 for patients without hypernatremia (P < .0001). Multivariate analysis showed that hypernatremia was an independent risk factor for hospital mortality with a relative risk (RR) of 1.40 (95% confidence interval, 1.34-1.45) and ICU LOS with a rate ratio (RtR) of 1.28 (1.26-1.30). The RR for mortality and RtR for ICU LOS increased with increasing severity strata of hypernatremia, but the duration of hypernatremia was not associated with mortality. CONCLUSIONS: Hypernatremia developed following ICU admission in 4.3% of patients. Hypernatremia was independently associated with a 40% increase in risk for hospital mortality and a 28% increase in ICU LOS. Severity, but not duration of ICU-acquired hypernatremia was associated with hospital mortality.
PURPOSE: The purpose of this study is to examine the impact of hypernatremia acquired after intensive care unit (ICU) admission on mortality and length of stay (LOS). MATERIALS AND METHODS: Data for this observational study were collected from patients admitted between January 1, 2008, and September 30, 2010 to 344 ICUs in the eICU Research Institute. RESULTS: Of the 207702 eligible patients, 8896 (4.3%) developed hypernatremia (serum Na >149 mEq/L). Hospital mortality was 32% for patients with hypernatremia and 11% for patients without hypernatremia (P < .0001). Intensive care unit LOS was 13.7 ± 9.7 days for patients with hypernatremia and 5.1 ± 4.6 for patients without hypernatremia (P < .0001). Multivariate analysis showed that hypernatremia was an independent risk factor for hospital mortality with a relative risk (RR) of 1.40 (95% confidence interval, 1.34-1.45) and ICU LOS with a rate ratio (RtR) of 1.28 (1.26-1.30). The RR for mortality and RtR for ICU LOS increased with increasing severity strata of hypernatremia, but the duration of hypernatremia was not associated with mortality. CONCLUSIONS:Hypernatremia developed following ICU admission in 4.3% of patients. Hypernatremia was independently associated with a 40% increase in risk for hospital mortality and a 28% increase in ICU LOS. Severity, but not duration of ICU-acquired hypernatremia was associated with hospital mortality.
Authors: Michael D Leise; Byung Cheol Yun; Joseph J Larson; Joanne T Benson; Ju Dong Yang; Terry M Therneau; Charles B Rosen; Julie K Heimbach; Scott W Biggins; W Ray Kim Journal: Liver Transpl Date: 2014-06 Impact factor: 5.799
Authors: Annemieke Oude Lansink-Hartgring; Lara Hessels; Joachim Weigel; Anne Marie G A de Smet; Diederik Gommers; Prashant V Nannan Panday; Ewout J Hoorn; Maarten W Nijsten Journal: Ann Intensive Care Date: 2016-03-17 Impact factor: 6.925
Authors: Edson A Nicolini; Roosevelt S Nunes; Gabriela V Santos; Silvana Lia da Silva; Mariana M Carreira; Fernanda G Pellison; Mayra G Menegueti; Maria Auxiliadora-Martins; Fernando Bellissimo-Rodrigues; Marcus A Feres; Anibal Basile-Filho Journal: Medicine (Baltimore) Date: 2017-03 Impact factor: 1.889