| Literature DB >> 23368752 |
Joseph M Langenhan1, Edouard Mullarky, Derek K Rogalsky, James R Rohlfing, Anja E Tjaden, Halina M Werner, Leonardo M Rozal, Steven A Loskot.
Abstract
The amphimedosides, discovered in 2006, are the first examples of naturally occurring glycosylated alkoxyamines. We report syntheses of amphimedosides A-C that feature a stereoselective oxyamine neoglycosylation and found that these alkaloids display modest cytotoxicity toward seven diverse human cancer cell lines, exhibiting IC(50) values ranging from 3.0 μM to greater than 100 μM.Entities:
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Year: 2013 PMID： 23368752 DOI： 10.1021/jo302640y
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354