BACKGROUND: Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies. OBJECTIVE: We aimed to identify susceptibility loci for drinking behavior (drinkers compared with nondrinkers) in Han Chinese. DESIGN: We performed 2 genome-wide association studies including 1420 drinkers and 3590 nondrinkers in discovery, followed by a de novo replication analysis comprising 4896 drinkers and 13,293 nondrinkers. DNA samples of the subjects were collected for genotyping. RESULTS: The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P < 5 × 10(-8)), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 × 10(-215)). Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 × 10(-35)). We also identified the association between rs11066280 and daily alcohol intake among drinkers (P-combined = 4.01 × 10(-21)). CONCLUSION: Our data indicate that common variants at 12q24 may contribute to the susceptibility of drinking behavior in Han Chinese.
BACKGROUND:Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies. OBJECTIVE: We aimed to identify susceptibility loci for drinking behavior (drinkers compared with nondrinkers) in Han Chinese. DESIGN: We performed 2 genome-wide association studies including 1420 drinkers and 3590 nondrinkers in discovery, followed by a de novo replication analysis comprising 4896 drinkers and 13,293 nondrinkers. DNA samples of the subjects were collected for genotyping. RESULTS: The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P < 5 × 10(-8)), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 × 10(-215)). Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 × 10(-35)). We also identified the association between rs11066280 and daily alcohol intake among drinkers (P-combined = 4.01 × 10(-21)). CONCLUSION: Our data indicate that common variants at 12q24 may contribute to the susceptibility of drinking behavior in Han Chinese.
Authors: Chunyu Liu; David Saffen; Thomas G Schulze; Margit Burmeister; Pak Chung Sham; Yong-Gang Yao; Po-Hsiu Kuo; Chao Chen; Yu An; Jiapei Dai; Weihua Yue; Miao Xin Li; Hong Xue; Bing Su; Li Chen; Yongyong Shi; Mingqi Qiao; Tiebang Liu; Kun Xia; Raymond C K Chan Journal: Mol Psychiatry Date: 2015-10-20 Impact factor: 15.992
Authors: Joel Gelernter; Ning Sun; Renato Polimanti; Robert H Pietrzak; Daniel F Levey; Qiongshi Lu; Yiming Hu; Boyang Li; Krishnan Radhakrishnan; Mihaela Aslan; Kei-Hoi Cheung; Yuli Li; Nallakkandi Rajeevan; Fred Sayward; Kelly Harrington; Quan Chen; Kelly Cho; Jacqueline Honerlaw; Saiju Pyarajan; Todd Lencz; Rachel Quaden; Yunling Shi; Haley Hunter-Zinck; J Michael Gaziano; Henry R Kranzler; John Concato; Hongyu Zhao; Murray B Stein Journal: Biol Psychiatry Date: 2019-04-08 Impact factor: 13.382
Authors: Joel Gelernter; Hang Zhou; Yaira Z Nuñez; Apiwat Mutirangura; Robert T Malison; Rasmon Kalayasiri Journal: Alcohol Clin Exp Res Date: 2018-03-13 Impact factor: 3.455
Authors: Eric R Gross; Vanessa O Zambelli; Bryce A Small; Julio C B Ferreira; Che-Hong Chen; Daria Mochly-Rosen Journal: Annu Rev Pharmacol Toxicol Date: 2014-09-29 Impact factor: 13.820
Authors: Sandra Sanchez-Roige; Pierre Fontanillas; Sarah L Elson; Joshua C Gray; Harriet de Wit; Lea K Davis; James MacKillop; Abraham A Palmer Journal: Addict Biol Date: 2017-10-23 Impact factor: 4.280
Authors: Ellen E Quillen; Xiang-Ding Chen; Laura Almasy; Fang Yang; Hao He; Xi Li; Xu-Yi Wang; Tie-Qiao Liu; Wei Hao; Hong-Wen Deng; Henry R Kranzler; Joel Gelernter Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2013-11-26 Impact factor: 3.568