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Literature DB >> 2336384

Echinomycin binding to the sequence CG(AT)nCG alters the structure of the central AT region.

Abstract

DNA fragments containing the sequence CG(AT)nCG have been used in footprinting experiments to assess the effect of echinomycin, which binds to CG steps, on the structure of the central AT region. DNAase I normally cuts ApT much better than TpA; in the presence of the drug this preference is retained but cleavage at TpA is enhanced. Changes in cleavage by micrococcal nuclease have also been observed. Echinomycin renders alternate adenines hyperreactive to diethylpyrocarbonate. The results suggest that echinomycin induces structural changes in regions surrounding its binding site and that these can be cooperatively propagated over several turns of the DNA helix.

Entities: Chemical

Mesh：

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Year: 1990 PMID： 2336384 PMCID： PMC330668 DOI： 10.1093/nar/18.8.1957

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

22 in total

1. Unstable Hoogsteen base pairs adjacent to echinomycin binding sites within a DNA duplex.

Authors: D E Gilbert; G A van der Marel; J H van Boom; J Feigon
Journal: Proc Natl Acad Sci U S A Date: 1989-05 Impact factor: 11.205

2. A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein.

Authors: A Klug; A Jack; M A Viswamitra; O Kennard; Z Shakked; T A Steitz
Journal: J Mol Biol Date: 1979-07-15 Impact factor: 5.469

3. Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.

Authors: C M Low; H R Drew; M J Waring
Journal: Nucleic Acids Res Date: 1984-06-25 Impact factor: 16.971

4. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

Authors: C Yanisch-Perron; J Vieira; J Messing
Journal: Gene Date: 1985 Impact factor: 3.688

5. Echinomycin binding sites on DNA.

Authors: M M Van Dyke; P B Dervan
Journal: Science Date: 1984-09-14 Impact factor: 47.728

6. The binding of echinomycin to deoxyribonucleic acid.

Authors: S P Wakelin; M J Waring
Journal: Biochem J Date: 1976-09-01 Impact factor: 3.857

7. Chemical probes reveal no evidence of Hoogsteen base pairing in complexes formed between echinomycin and DNA in solution.

Authors: M J McLean; M J Waring
Journal: J Mol Recognit Date: 1988-06 Impact factor: 2.137

8. The molecular structure of a DNA-triostin A complex.

Authors: A H Wang; G Ughetto; G J Quigley; T Hakoshima; G A van der Marel; J H van Boom; A Rich
Journal: Science Date: 1984-09-14 Impact factor: 47.728

9. Actinomycin D induced DNase I cleavage enhancement caused by sequence specific propagation of an altered DNA structure.

Authors: Y Q Huang; R P Rehfuss; S R LaPlante; E Boudreau; P N Borer; M J Lane
Journal: Nucleic Acids Res Date: 1988-12-09 Impact factor: 16.971

10. DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting.

Authors: K R Fox; M J Waring
Journal: Nucleic Acids Res Date: 1984-12-21 Impact factor: 16.971

8 in total

1. Interaction of echinomycin with An.Tn. and (AT)n regions flanking its CG binding site.

Authors: K Waterloh; K R Fox
Journal: Nucleic Acids Res Date: 1991-12-25 Impact factor: 16.971

2. Proton NMR study of the [d(ACGTATACGT)]2-2echinomycin complex: conformational changes between echinomycin binding sites.

Authors: D E Gilbert; J Feigon
Journal: Nucleic Acids Res Date: 1992-05-25 Impact factor: 16.971

3. Infrared linear dichroism studies of DNA-drug complexes: quantitative determination of the drug-induced restriction of the B-A transition.

Authors: H Fritzsche
Journal: Nucleic Acids Res Date: 1994-03-11 Impact factor: 16.971