Literature DB >> 23362121

Small-molecule-mediated axonal branching in Caenorhabditis elegans.

Katherine Zlotkowski1, Jon Pierce-Shimomura, Dionicio Siegel.   

Abstract

An in vivo system for monitoring small-molecule-mediated neuronal branching has been developed by using C. elegans. Growth-promoting compounds can be detected by visual inspection of GFPlabeled cholinergic neurons, as axonal branching occurs following treatment with neurotrophic agents. Investigation of the structure-activity relationship of the neurotrophic natural product clovanemagnolol (1) led us to a comparable chemically edited derivative.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23362121      PMCID： PMC4470382          DOI： 10.1002/cbic.201200712

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  26 in total

1.  Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches.

Authors:  E W Dent; J L Callaway; G Szebenyi; P W Baas; K Kalil
Journal:  J Neurosci       Date:  1999-10-15       Impact factor: 6.167

2.  Axon branching requires interactions between dynamic microtubules and actin filaments.

Authors:  E W Dent; K Kalil
Journal:  J Neurosci       Date:  2001-12-15       Impact factor: 6.167

3.  cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

Authors:  R E Rydel; L A Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

Review 4.  Maintenance of C. elegans.

Authors:  Theresa Stiernagle
Journal:  WormBook       Date:  2006-02-11

5.  Green fluorescent protein as a marker for gene expression.

Authors:  M Chalfie; Y Tu; G Euskirchen; W W Ward; D C Prasher
Journal:  Science       Date:  1994-02-11       Impact factor: 47.728

6.  Spontaneous age-related neurite branching in Caenorhabditis elegans.

Authors:  Elizabeth M H Tank; Kasey E Rodgers; Cynthia Kenyon
Journal:  J Neurosci       Date:  2011-06-22       Impact factor: 6.167

Review 7.  Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research.

Authors:  S Elizabeth Hulme; George M Whitesides
Journal:  Angew Chem Int Ed Engl       Date:  2011-04-15       Impact factor: 15.336

Review 8.  Finding function in novel targets: C. elegans as a model organism.

Authors:  Titus Kaletta; Michael O Hengartner
Journal:  Nat Rev Drug Discov       Date:  2006-05       Impact factor: 84.694

9.  A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Authors:  Andrew R Burns; Iain M Wallace; Jan Wildenhain; Mike Tyers; Guri Giaever; Gary D Bader; Corey Nislow; Sean R Cutler; Peter J Roy
Journal:  Nat Chem Biol       Date:  2010-05-30       Impact factor: 15.040

10.  The genetics of Caenorhabditis elegans.

Authors:  S Brenner
Journal:  Genetics       Date:  1974-05       Impact factor: 4.562
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  2 in total

Review 1.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

2.  Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line.

Authors:  Harris A Weisz; Deborah R Boone; William S Coggins; Gabrielle A Edwards; Hannah E Willey; Steven G Widen; Dionicio Siegel; Andrew T Nelson; Donald S Prough; Helen L Hellmich
Journal:  PLoS One       Date:  2022-06-03       Impact factor: 3.752
  2 in total

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