Literature DB >> 23362068

Stroke due to typical thrombotic thrombocytopenic purpura treated successfully with intravenous thrombolysis and therapeutic plasma exchange.

Matteo Boattini1, Gaetano Procaccianti.   

Abstract

We report a case of a 39-year-old man with expressive aphasia due to occlusion of the temporal stem of the left middle cerebral artery. Laboratory tests showed microangiopathic haemolytic anaemia and thrombocytopenia. A thrombotic thrombocytopenic purpura (TTP) was diagnosed, and thrombolytic therapy (TT) with alteplase followed by therapeutic plasma exchange (TPE) were performed with complete resolution of symptoms. The gold standard TTP treatment is TPE, and its delay can be lethal. The use of TT in TTP is controversial and has potential risks. This case shows a successful TT in a patient with typical TTP presenting as a stroke due to a large cerebral artery occlusion.

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Year:  2013        PMID： 23362068      PMCID： PMC3604442          DOI： 10.1136/bcr-2012-008426

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  9 in total

1.  Atypical thrombotic thrombocytopenic purpura in a middle-aged woman who presented with a recurrent stroke.

Authors:  Modupe Idowu; Preethi Reddy
Journal:  Am J Hematol       Date:  2012-05-28       Impact factor: 10.047

2.  Survival and relapse in patients with thrombotic thrombocytopenic purpura.

Authors:  Johanna A Kremer Hovinga; Sara K Vesely; Deirdra R Terrell; Bernhard Lämmle; James N George
Journal:  Blood       Date:  2009-12-23       Impact factor: 22.113

3.  Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure.

Authors:  Tomoko Ono; Jun Mimuro; Seiji Madoiwa; Kenji Soejima; Yuji Kashiwakura; Akira Ishiwata; Katsuhiro Takano; Tsukasa Ohmori; Yoichi Sakata
Journal:  Blood       Date:  2005-09-27       Impact factor: 22.113

4.  Stroke in a young patient treated by alteplase heralding an acquired thrombotic thrombocytopenic purpura.

Authors:  Amandine Sevy; Emilie Doche; Christian Squarcioni; Pascale Poullin; Jacques Serratrice; Francois Nicoli; Pierre-Jean Weiller
Journal:  J Clin Apher       Date:  2010-12-13       Impact factor: 2.821

5.  Thrombotic thrombocytopenic purpura mimicking acute ischemic stroke.

Authors:  E Aksay; S Kiyan; M Ersel; O Hudaverdi
Journal:  Emerg Med J       Date:  2006-09       Impact factor: 2.740

6.  Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.

Authors:  Harold P Adams; Gregory del Zoppo; Mark J Alberts; Deepak L Bhatt; Lawrence Brass; Anthony Furlan; Robert L Grubb; Randall T Higashida; Edward C Jauch; Chelsea Kidwell; Patrick D Lyden; Lewis B Morgenstern; Adnan I Qureshi; Robert H Rosenwasser; Phillip A Scott; Eelco F M Wijdicks
Journal:  Stroke       Date:  2007-04-12       Impact factor: 7.914

7.  von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.

Authors:  M Furlan; R Robles; M Galbusera; G Remuzzi; P A Kyrle; B Brenner; M Krause; I Scharrer; V Aumann; U Mittler; M Solenthaler; B Lämmle
Journal:  N Engl J Med       Date:  1998-11-26       Impact factor: 91.245

8.  Relapsed thrombotic thrombocytopenic purpura presenting as an acute cerebrovascular accident.

Authors:  Katharine A Downes; Roslyn Yomtovian; H M Tsai; Bernard Silver; Cynthia Rutherford; Ravindra Sarode
Journal:  J Clin Apher       Date:  2004       Impact factor: 2.821

9.  Increasing mortality from thrombotic thrombocytopenic purpura in the United States--analysis of national mortality data, 1968-1991.

Authors:  T J Török; R C Holman; T L Chorba
Journal:  Am J Hematol       Date:  1995-10       Impact factor: 10.047
  9 in total
  5 in total

1.  Acute Middle Cerebral Artery Occlusion Treated by Thrombectomy in a Patient with Myelodysplastic Syndrome and Severe Thrombocytopenia.

Authors:  Halil Onder; E Murat Arsava; Anıl Arat; M Akif Topcuoglu
Journal:  J Vasc Interv Neurol       Date:  2015-10

2.  Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura.

Authors:  X Long Zheng; Sara K Vesely; Spero R Cataland; Paul Coppo; Brian Geldziler; Alfonso Iorio; Masanori Matsumoto; Reem A Mustafa; Menaka Pai; Gail Rock; Lene Russell; Rawan Tarawneh; Julie Valdes; Flora Peyvandi
Journal:  J Thromb Haemost       Date:  2020-09-11       Impact factor: 5.824

Review 3.  Neurologic Complications in the Intensive Care Unit.

Authors:  Clio Rubinos; Sean Ruland
Journal:  Curr Neurol Neurosci Rep       Date:  2016-06       Impact factor: 5.081

4.  Cerebral Infarction in Immune Thrombotic Thrombocytopenic Purpura Is Associated with Old Age, Hypertension, Smoking, and Anti-ADAMTS13 Ig, But Not with Mortality.

Authors:  Raima Memon; Jingrui Sui; Chen Lin; X Long Zheng
Journal:  TH Open       Date:  2021-01-13

5.  Thrombotic Thrombocytopenic Purpura Masquerading as Acute Ischemic Stroke.

Authors:  Asia Filatov; Emily Kassar; Oladipo Cole
Journal:  Cureus       Date:  2020-04-13
  5 in total

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