Literature DB >> 23361916

The mechanism of caseinolytic protease (ClpP) inhibition.

Malte Gersch1, Felix Gut, Vadim S Korotkov, Johannes Lehmann, Thomas Böttcher, Marion Rusch, Christian Hedberg, Herbert Waldmann, Gerhard Klebe, Stephan A Sieber.   

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Year:  2013        PMID： 23361916     DOI： 10.1002/anie.201204690

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  10 in total

1.  Clostridium difficile ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation.

Authors:  Nathan P Lavey; Tyler Shadid; Jimmy D Ballard; Adam S Duerfeldt
Journal:  ACS Infect Dis       Date:  2018-11-26       Impact factor: 5.084

2.  Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.

Authors:  Evelyn Zeiler; Anja List; Ferdinand Alte; Malte Gersch; Rudolf Wachtel; Marcin Poreba; Marcin Drag; Michael Groll; Stephan A Sieber
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-24       Impact factor: 11.205

3.  Development of a bioorthogonal fluorescence-based assay for assessing drug uptake and delivery in bacteria.

Authors:  Jocelyn M F Ooi; Jessica M Fairhall; Benjamin Spangler; Daniel J W Chong; Brian Y Feng; Allan B Gamble; Sarah Hook
Journal:  RSC Adv       Date:  2022-05-23       Impact factor: 4.036

4.  Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.

Authors:  Corey L Compton; Karl R Schmitz; Robert T Sauer; Jason K Sello
Journal:  ACS Chem Biol       Date:  2013-10-04       Impact factor: 5.100

5.  Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.

Authors:  Karl R Schmitz; Robert T Sauer
Journal:  Mol Microbiol       Date:  2014-07-13       Impact factor: 3.501

Review 6.  Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential.

Authors:  Heike Brötz-Oesterhelt; Andreas Vorbach
Journal:  Front Mol Biosci       Date:  2021-05-13

7.  Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.

Authors:  Wilfried Moreira; Grace J Y Ngan; Jian Liang Low; Anders Poulsen; Brian C S Chia; Melgious J Y Ang; Amelia Yap; Justina Fulwood; Umayal Lakshmanan; Jolander Lim; Audrey Y T Khoo; Horst Flotow; Jeffrey Hill; Ravikiran M Raju; Eric J Rubin; Thomas Dick
Journal:  MBio       Date:  2015-05-05       Impact factor: 7.867

8.  Exploring anti-bacterial compounds against intracellular Legionella.

Authors:  Christopher F Harrison; Sébastien Kicka; Valentin Trofimov; Kathrin Berschl; Hajer Ouertatani-Sakouhi; Nikolaus Ackermann; Christian Hedberg; Pierre Cosson; Thierry Soldati; Hubert Hilbi
Journal:  PLoS One       Date:  2013-09-13       Impact factor: 3.240

Review 9.  Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy.

Authors:  Kazem Nouri; Yue Feng; Aaron D Schimmer
Journal:  Cell Death Dis       Date:  2020-10-09       Impact factor: 8.469

10.  ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway.

Authors:  Juan Luo; Beilei Zeng; Chunfang Tao; Mengqi Lu; Guosheng Ren
Journal:  PeerJ       Date:  2020-03-10       Impact factor: 2.984
  10 in total

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