BACKGROUND: For early-stage oral squamous cell carcinoma (OSCC) patients, the impact of perineural invasion (PNI) and lymphovascular invasion (LVI) on disease control and survival has not been clarified. METHODS: The medical records of all early-stage OSCC patients who underwent curative surgery between 2004 and 2009 were reviewed. RESULTS: A total of 442 early stage patients were included in this study. There were 360 patients in group A (without PNI or LVI) and 82 patients in group B (with PNI and/or LVI). Between groups A and B patients, there were no significant differences in the 5-year disease-free survival (73.8 vs 68.7 %, p = 0.48) and overall survival (90.9 vs 86.1 %, p = 0.25). Between groups A and B patients without postoperative radiotherapy (PORT), there were no significant differences in the 5-year disease-free survival (73.8 vs 70.2 %, p = 0.51) and overall survival (90.9 vs 85.2 %, p = 0.18). Between group B patients with and without PORT, there was no significant difference in either the disease-free survival (61.1 vs 70.2 %, p = 0.98) and overall survival (88.9 vs 85.2 %, p = 0.64). Multivariate analyses revealed that PNI, LVI, and PORT could not provide significant effect on treatment outcome. CONCLUSIONS: PNI and LVI were not significant risk factors for the disease control and overall survival for early stage OSCC patients. Furthermore, PORT could not provide an additional benefit for the disease control and overall survival for stages I and II OSCC patients with PNI and/or LVI.
BACKGROUND: For early-stage oral squamous cell carcinoma (OSCC) patients, the impact of perineural invasion (PNI) and lymphovascular invasion (LVI) on disease control and survival has not been clarified. METHODS: The medical records of all early-stage OSCC patients who underwent curative surgery between 2004 and 2009 were reviewed. RESULTS: A total of 442 early stage patients were included in this study. There were 360 patients in group A (without PNI or LVI) and 82 patients in group B (with PNI and/or LVI). Between groups A and B patients, there were no significant differences in the 5-year disease-free survival (73.8 vs 68.7 %, p = 0.48) and overall survival (90.9 vs 86.1 %, p = 0.25). Between groups A and B patients without postoperative radiotherapy (PORT), there were no significant differences in the 5-year disease-free survival (73.8 vs 70.2 %, p = 0.51) and overall survival (90.9 vs 85.2 %, p = 0.18). Between group B patients with and without PORT, there was no significant difference in either the disease-free survival (61.1 vs 70.2 %, p = 0.98) and overall survival (88.9 vs 85.2 %, p = 0.64). Multivariate analyses revealed that PNI, LVI, and PORT could not provide significant effect on treatment outcome. CONCLUSIONS: PNI and LVI were not significant risk factors for the disease control and overall survival for early stage OSCC patients. Furthermore, PORT could not provide an additional benefit for the disease control and overall survival for stages I and II OSCC patients with PNI and/or LVI.
Authors: A Tuba Kendi; Amanda Corey; Kelly R Magliocca; Dana C Nickleach; James Galt; Jeffrey M Switchenko; Mark W El-Deiry; J Trad Wadsworth; Patricia A Hudgins; Nabil F Saba; David M Schuster Journal: Eur J Radiol Date: 2015-03-14 Impact factor: 3.528
Authors: Eran Fridman; Shorook Na'ara; Jaiprakash Agarwal; Moran Amit; Gideon Bachar; Andrea Bolzoni Villaret; Jose Brandao; Claudio R Cernea; Pankaj Chaturvedi; Jonathan Clark; Ardalan Ebrahimi; Dan M Fliss; Sashikanth Jonnalagadda; Hugo F Kohler; Luiz P Kowalski; Matthias Kreppel; Chun-Ta Liao; Snehal G Patel; Rajan S Patel; K Thomas Robbins; Jatin P Shah; Thomas Shpitzer; Tzu-Chen Yen; Joachim E Zöller; Ziv Gil Journal: Cancer Date: 2018-05-14 Impact factor: 6.860
Authors: William G Albergotti; Hannah L Schwarzbach; Shira Abberbock; Robert L Ferris; Jonas T Johnson; Umamaheswar Duvvuri; Seungwon Kim Journal: JAMA Otolaryngol Head Neck Surg Date: 2017-12-01 Impact factor: 6.223
Authors: Christoph Klingelhöffer; Andreas Gründlinger; Gerrit Spanier; Stephan Schreml; Maximilian Gottsauner; Steffen Mueller; Johannes K Meier; Torsten E Reichert; Tobias Ettl Journal: Oral Maxillofac Surg Date: 2018-03-29