Elizabeth S Langen1, Eliza F Chakravarty2, Maryam Liaquat3, Yasser Y El-Sayed1, Maurice L Druzin1. 1. Department of Obstetrics and Gynecology, Stanford University, Stanford, California. 2. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma. 3. Medical School, University of Utah, Salt Lake City, Utah.
Abstract
OBJECTIVE: To describe the outcomes of pregnancies complicated by rheumatoid arthritis (RA) and to estimate potential associations between disease characteristics and pregnancy outcomes. STUDY DESIGN: We reviewed all pregnancies complicated by RA delivered at our institution from June 2001 through June 2009. Fisher exact tests were used to calculate odds ratios. Univariable regression was performed using STATA 10.1 (StataCorp, College Station, TX). A p value of ≤ 0.05 was considered statistically significant. RESULTS: Forty-six pregnancies in 40 women were reviewed. Sixty percent of pregnancies had evidence of disease flare and 28% delivered prior to 37 weeks. We did not identify associations between preterm birth and active disease at conception or during pregnancy. In univariate analysis, discontinuation of medication because of pregnancy was associated with a significantly earlier gestational age at delivery (362/7 versus 383/7 weeks, p = 0.022). CONCLUSION: Women with RA may be at higher risk for preterm delivery. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: To describe the outcomes of pregnancies complicated by rheumatoid arthritis (RA) and to estimate potential associations between disease characteristics and pregnancy outcomes. STUDY DESIGN: We reviewed all pregnancies complicated by RA delivered at our institution from June 2001 through June 2009. Fisher exact tests were used to calculate odds ratios. Univariable regression was performed using STATA 10.1 (StataCorp, College Station, TX). A p value of ≤ 0.05 was considered statistically significant. RESULTS: Forty-six pregnancies in 40 women were reviewed. Sixty percent of pregnancies had evidence of disease flare and 28% delivered prior to 37 weeks. We did not identify associations between preterm birth and active disease at conception or during pregnancy. In univariate analysis, discontinuation of medication because of pregnancy was associated with a significantly earlier gestational age at delivery (362/7 versus 383/7 weeks, p = 0.022). CONCLUSION:Women with RA may be at higher risk for preterm delivery. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Ane L Rom; Chun S Wu; Jørn Olsen; Damini Jawaheer; Merete L Hetland; Bent Ottesen; Lina S Mørch Journal: Arthritis Care Res (Hoboken) Date: 2017-05-08 Impact factor: 4.794
Authors: Chelsey J F Smith; Frauke Förger; Gretchen Bandoli; Christina D Chambers Journal: Arthritis Care Res (Hoboken) Date: 2019-07-04 Impact factor: 4.794
Authors: K D Kolstad; J A Mayo; L Chung; Y Chaichian; V M Kelly; M Druzin; D K Stevenson; G M Shaw; J F Simard Journal: BJOG Date: 2019-10-31 Impact factor: 6.531
Authors: Gretchen Bandoli; Namrata Singh; Jennifer Strouse; Rebecca J Baer; Brittney M Donovan; Sky K Feuer; Nichole Nidey; Kelli K Ryckman; Laura L Jelliffe-Pawlowski; Christina D Chambers Journal: Arthritis Care Res (Hoboken) Date: 2020-01-09 Impact factor: 4.794