Literature DB >> 23358515

Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?

Giovanni D'Arena1, Vittorio Simeon, Fiorella D'Auria, Teodora Statuto, Paola Di Sanzo, Laura De Martino, Aurelio Marandino, Michele Sangiorgio, Pellegrino Musto, Vincenzo De Feo.   

Abstract

Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a prognostic indicator of the disease clinical course.

Entities:  

Keywords:  Tregs; chronic lymphocytic leukemia; prognosis

Year:  2013        PMID： 23358515      PMCID： PMC3555189     

Source DB:  PubMed          Journal:  Am J Blood Res        ISSN： 2160-1992


  41 in total

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3.  Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.

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4.  Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine.

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Journal:  Blood       Date:  2005-05-24       Impact factor: 22.113

Review 5.  Regulatory T cells in cancer.

Authors:  Marc Beyer; Joachim L Schultze
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Review 6.  Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy.

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  11 in total

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2.  PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia.

Authors:  Bola S Hanna; Philipp M Roessner; Annika Scheffold; Billy M C Jebaraj; Yasmin Demerdash; Selcen Öztürk; Peter Lichter; Stephan Stilgenbauer; Martina Seiffert
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Review 4.  Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies.

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5.  Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.

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6.  Revisiting Autoimmunity in Chronic Lymphocytic Leukemia: Prognostic Value of Positive Direct Antiglobulin Test in a Retrospective Study and Literature Review.

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Review 7.  T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?

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Review 9.  Regulatory T cells in allogeneic stem cell transplantation.

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10.  Increased frequencies of Th17 in the peripheral blood of patients with chronic lymphocytic leukemia: A one year follow-up.

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