Literature DB >> 23357848

Niche-less maintenance of HSCs by 2i.

Shigeo Masuda1, Mo Li, Juan Carlos Izpisua Belmonte.   

Abstract

Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

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Year:  2013        PMID： 23357848      PMCID： PMC3616430          DOI： 10.1038/cr.2013.14

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  A role for Wnt signalling in self-renewal of haematopoietic stem cells.

Authors:  Tannishtha Reya; Andrew W Duncan; Laurie Ailles; Jos Domen; David C Scherer; Karl Willert; Lindsay Hintz; Roel Nusse; Irving L Weissman
Journal:  Nature       Date:  2003-04-27       Impact factor: 49.962

Review 2.  Wnt signalling in stem cells and cancer.

Authors:  Tannishtha Reya; Hans Clevers
Journal:  Nature       Date:  2005-04-14       Impact factor: 49.962

Review 3.  Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways.

Authors:  Michael J Nemeth; David M Bodine
Journal:  Cell Res       Date:  2007-09       Impact factor: 25.617

Review 4.  Quiescence regulators for hematopoietic stem cell.

Authors:  June Li
Journal:  Exp Hematol       Date:  2011-02-01       Impact factor: 3.084

Review 5.  Ex vivo expansion of human hematopoietic stem and progenitor cells.

Authors:  Ann Dahlberg; Colleen Delaney; Irwin D Bernstein
Journal:  Blood       Date:  2011-03-23       Impact factor: 22.113

6.  Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.

Authors:  John M Perry; Xi C He; Ryohichi Sugimura; Justin C Grindley; Jeffrey S Haug; Sheng Ding; Linheng Li
Journal:  Genes Dev       Date:  2011-09-02       Impact factor: 11.361

7.  Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice.

Authors:  Jian Huang; Yi Zhang; Alexey Bersenev; W Timothy O'Brien; Wei Tong; Stephen G Emerson; Peter S Klein
Journal:  J Clin Invest       Date:  2009-12       Impact factor: 14.808

8.  Cancer morbidity in psychiatric patients: influence of lithium carbonate treatment.

Authors:  Y Cohen; A Chetrit; Y Cohen; P Sirota; B Modan
Journal:  Med Oncol       Date:  1998-04       Impact factor: 3.064

9.  Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

Authors:  Heather E Fleming; Viktor Janzen; Cristina Lo Celso; Jun Guo; Kathleen M Leahy; Henry M Kronenberg; David T Scadden
Journal:  Cell Stem Cell       Date:  2008-03-06       Impact factor: 24.633

Review 10.  Dynamic niches in the origination and differentiation of haematopoietic stem cells.

Authors:  Leo D Wang; Amy J Wagers
Journal:  Nat Rev Mol Cell Biol       Date:  2011-09-02       Impact factor: 94.444
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  2 in total

1.  Analysis of Hematopoietic Stem Progenitor Cell Metabolism.

Authors:  Giorgia Scapin; Marie C Goulard; Priyanka R Dharampuriya; Jennifer L Cillis; Dhvanit I Shah
Journal:  J Vis Exp       Date:  2019-11-09       Impact factor: 1.355

2.  Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells.

Authors:  Elnaz Farahbakhshian; Monique M Verstegen; Trudi P Visser; Sima Kheradmandkia; Dirk Geerts; Shazia Arshad; Noveen Riaz; Frank Grosveld; Niek P van Til; Jules P P Meijerink
Journal:  PLoS One       Date:  2014-08-29       Impact factor: 3.240
  2 in total

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