The relationship between self-reported nocturnal sleep duration, daytime sleepiness and 24-h urinary albumin and protein excretion in patients with newly diagnosed type 2 diabetes.

AIM: In the current study the relationship between self-reported nocturnal sleep duration (NSD) and daytime sleepiness with 24-h urinary protein excretion (UPE) and 24-h urinary albumin excretion (UAE) were investigated in patients with newly diagnosed type 2 diabetes mellitus.
METHODS: All patients underwent history taking, physical examination, blood pressure (BP) measurement, 12 lead electrocardiographic evaluation, routine urine analysis, biochemical analysis, 24-h urine collection to measure UAE, UPE and creatinine clearance. Self reported NSD and daytime sleepiness (using Epworth Sleepiness Scale (ESS)) were recorded for all patients.
RESULTS: In total 110 patients (56 male and 54 female) were included. Self reported NSD was 7.17 ± 1.07 h. Mean ESS score was 5.59 ± 2.48. Stepwise linear regression of independent factors revealed that logarithmically converted 24-h UAE (as a dependent parameter) was related with clinical systolic BP (b: 0.01, p: 0.003), HbA1c (b: 0.082, p: 0.033), self reported NSD (b: -0.152, p: 0.004) and ESS score (b: 0.044, p: 0.043). Additionally, on the other hand, 24-h UPE was related with clinical systolic BP (b: 0.011, p: 0.001) and self reported NSD (b: -0.179, p<0.0001) in regression analysis.
CONCLUSION: In conclusion, 24-h UAE were independently related with self reported NSD and daytime sleepiness where as 24-h UPE was related with only NSD in patients with newly diagnosed type 2 diabetic patients.