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The role of palmitoylation in regulating Ras localization and function.

Sharon Eisenberg¹, Alex J Laude, Alison J Beckett, Craig J Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I Henis, Ian A Prior.

Abstract

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

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Year: 2013 PMID： 23356262 DOI： 10.1042/BST20120268

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

29 in total

1. ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.

Authors: Patricia Marie-Jeanne Lievens; Tatiana Kuznetsova; Gaga Kochlamazashvili; Fabrizia Cesca; Natalya Gorinski; Dalia Abdel Galil; Volodimir Cherkas; Natalia Ronkina; Juri Lafera; Matthias Gaestel; Evgeni Ponimaskin; Alexander Dityatev
Journal: Mol Cell Biol Date: 2016-08-12 Impact factor: 4.272

The role of palmitoylation in regulating Ras localization and function.

1. ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.

2. Single-cell in situ imaging of palmitoylation in fatty-acylated proteins.

3. Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking.

Review 4. Oncogenic Ras Isoforms Signaling Specificity at the Membrane.

5. Mechanisms by Which Pleiotropic Amphiphilic n-3 PUFA Reduce Colon Cancer Risk.

6. Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.

7. Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling.

8. Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors.

9. Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans.

10. Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity.