| Literature DB >> 23355337 |
Ze-Kun Zhao1, Wen-Guang Wu, Lei Chen, Ping Dong, Jun Gu, Jia-Sheng Mu, Jia-Hua Yang, Ying-Bin Liu.
Abstract
The aim of this current study was to investigate the clinicopathologic features and prognostic significance of UbcH10 in pancreatic ductal adenocarcinoma (PDA). Real-time quantitative RT-PCR was employed to examine UbcH10 expression in 20 pairs of PDA and adjacent non-cancerous tissues. In addition, UbcH10 expression was analyzed by immunohistochemistry in 94 clinicopathologically characterized PDA cases. The correlation of UbcH10 expression with patients' survival rate was assessed by Kaplan-Meier and Cox regression. Our results showed that the expression levels of UbcH10 mRNA and protein in PDA tissues were both significantly higher than those in non-cancerous tissues. Simultaneously, high expression of UbcH10 was significantly correlated with the clinical stage (p<0.001), degree of histological differentiation (p<0.001), and lymph node metastasis (p=0.001). Moreover, high expression of UbcH10 was significantly associated with poor overall survival in PDA patients. In conclusion, UbcH10 might play a positive role in tumor development and could serve as an independent predictor of poor prognosis for PDA.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23355337 DOI： 10.1007/s13277-013-0671-9
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283