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Literature DB >> 23354413

Rictor encounters RhoGDI2: the second pilot is taking a lead.

Nitin K Agarwal¹, Dubek Kazyken, Dos D Sarbassov.

Abstract

Rictor's role in cell migration has been first indicated in the original chemotaxis studies in Dictyostelium and more recent studies reported that rictor is required for migration of cancer cells. How rictor promotes cell migration remains poorly characterized. Based on our proteomics study we have identified a novel functional role of rictor in regulation of cell migration. Here, we discuss our recent finding that rictor by suppressing RhoGDI2 maintains activity of the Rac1/cdc42 GTPases and promotes cell migration. Our finding outlines a critical role of rictor in the regulation of RhoGDI2 activity. This study opens new avenues in the investigation of cancer metastasis by analyzing the rictor dependent post-translational modification of RhoGDI2.

Entities: Disease Gene

Keywords: Rac1; Rho GTPases; RhoGDI2; cell migration; rictor

Mesh：

Substances：

Year: 2013 PMID： 23354413 PMCID： PMC3747249 DOI： 10.4161/sgtp.23346

Source DB: PubMed Journal: Small GTPases ISSN： 2154-1248

31 in total

1. How RhoGDI binds Rho.

Authors: K Longenecker; P Read; U Derewenda; Z Dauter; X Liu; S Garrard; L Walker; A V Somlyo; R K Nakamoto; A P Somlyo; Z S Derewenda
Journal: Acta Crystallogr D Biol Crystallogr Date: 1999-09

2. Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.

Authors: Céline DerMardirossian; Gabriel Rocklin; Ji-Yeon Seo; Gary M Bokoch
Journal: Mol Biol Cell Date: 2006-08-30 Impact factor: 4.138

Review 3. RhoGDI: multiple functions in the regulation of Rho family GTPase activities.

Authors: Athanassios Dovas; John R Couchman
Journal: Biochem J Date: 2005-08-15 Impact factor: 3.857

Review 4. RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs.

Authors: E Dransart; A Morin; J Cherfils; B Olofsson
Journal: Biochem Soc Trans Date: 2005-08 Impact factor: 5.407

5. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium.

Authors: M Y Chen; Y Long; P N Devreotes
Journal: Genes Dev Date: 1997-12-01 Impact factor: 11.361

Review 6. Growing roles for the mTOR pathway.

Authors: Dos D Sarbassov; Siraj M Ali; David M Sabatini
Journal: Curr Opin Cell Biol Date: 2005-10-13 Impact factor: 8.382

7. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2.

Authors: Brian Titus; Henry F Frierson; Mark Conaway; Keith Ching; Theresa Guise; John Chirgwin; Garret Hampton; Dan Theodorescu
Journal: Cancer Res Date: 2005-08-15 Impact factor: 12.701

8. Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis.

Authors: Li De Hu; Hua Fei Zou; Shu Xuan Zhan; Kai Ming Cao
Journal: Oncol Rep Date: 2007-06 Impact factor: 3.906