BACKGROUND: We noted only rare reports of cirrhotic patients with bacterial endocarditis (BE). There is insufficient data on the risk of BE in liver cirrhosis. This is the first national population-based study evaluating the risk of BE in cirrhotic patients. METHODS: We used the National Health Insurance Database, which is derived from the Taiwan National Health Insurance Program. The study cohort comprised 40803 patients with cirrhosis and the comparison cohort consisted of 40841 randomly selected subjects with a similar age and sex distribution. RESULTS: Of the total 81644 patients, 192 (0.24%) experienced BE during the 3-year follow-up period, 121 patients from the study cohort (0.30% of the cirrhotic patients) and 71 patients from the comparison group (0.17% of non-cirrhotic patients) (p<0.001). After adjusting for patient age, sex, and comorbid disorders, the Cox regression analysis showed that cirrhotic patients had a high risk of BE compared to non-cirrhotic patients during the 3-year follow-up period (hazard ratio 2.04, 95% confidence interval 1.61-2.44, p<0.001). CONCLUSION: We conclude that liver cirrhosis is a risk factor for the occurrence of BE.
BACKGROUND: We noted only rare reports of cirrhotic patients with bacterial endocarditis (BE). There is insufficient data on the risk of BE in liver cirrhosis. This is the first national population-based study evaluating the risk of BE in cirrhotic patients. METHODS: We used the National Health Insurance Database, which is derived from the Taiwan National Health Insurance Program. The study cohort comprised 40803 patients with cirrhosis and the comparison cohort consisted of 40841 randomly selected subjects with a similar age and sex distribution. RESULTS: Of the total 81644 patients, 192 (0.24%) experienced BE during the 3-year follow-up period, 121 patients from the study cohort (0.30% of the cirrhotic patients) and 71 patients from the comparison group (0.17% of non-cirrhotic patients) (p<0.001). After adjusting for patient age, sex, and comorbid disorders, the Cox regression analysis showed that cirrhotic patients had a high risk of BE compared to non-cirrhotic patients during the 3-year follow-up period (hazard ratio 2.04, 95% confidence interval 1.61-2.44, p<0.001). CONCLUSION: We conclude that liver cirrhosis is a risk factor for the occurrence of BE.
Authors: E Seminari; A De Silvestri; V Ravasio; S Ludovisi; R Utili; N Petrosillo; F Castelli; M Bassetti; F Barbaro; P Grossi; N Barzaghi; M Rizzi; L Minoli Journal: Eur J Clin Microbiol Infect Dis Date: 2015-12-21 Impact factor: 3.267
Authors: Andrew J Monteith; Jeanette M Miller; William N Beavers; Lillian J Juttukonda; Eric P Skaar Journal: Infect Immun Date: 2022-01-18 Impact factor: 3.609
Authors: Lillian J Juttukonda; Evelien T M Berends; Joseph P Zackular; Jessica L Moore; Matthew T Stier; Yaofang Zhang; Jonathan E Schmitz; William N Beavers; Christiaan D Wijers; Benjamin A Gilston; Thomas E Kehl-Fie; James Atkinson; Mary K Washington; R Stokes Peebles; Walter J Chazin; Victor J Torres; Richard M Caprioli; Eric P Skaar Journal: Cell Host Microbe Date: 2017-09-21 Impact factor: 21.023