Literature DB >> 2335223

The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation.

H Wiseman1, M J Laughton, H R Arnstein, M Cannon, B Halliwell.   

Abstract

The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.

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Year:  1990        PMID： 2335223     DOI： 10.1016/0014-5793(90)81371-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

Review 1.  Review of progress in sterol oxidations: 1987-1995.

Authors:  L L Smith
Journal:  Lipids       Date:  1996-05       Impact factor: 1.880

2.  Effect of exercise on tissue anti-oxidant capacity and heart electrical properties in male and female rats.

Authors:  P Venditti; M C Piro; G Artiaco; S Di Meo
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1996

3.  Combined efficacy of tamoxifen and coenzyme Q10 on the status of lipid peroxidation and antioxidants in DMBA induced breast cancer.

Authors:  Selvanathan Saravana Perumal; Palanivelu Shanthi; Panchanadham Sachdanandam
Journal:  Mol Cell Biochem       Date:  2005-05       Impact factor: 3.396

4.  Tamoxifen inhibits acidification in cells independent of the estrogen receptor.

Authors:  N Altan; Y Chen; M Schindler; S M Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

5.  Antioxidant benefits of tamoxifen therapy for breast cancer?

Authors:  H Wiseman; C Rice-Evans; B Halliwell
Journal:  Breast Cancer Res Treat       Date:  1994       Impact factor: 4.872

Review 6.  Cardiotoxicity of aromatase inhibitors and tamoxifen in postmenopausal women with breast cancer: a systematic review and meta-analysis of randomized controlled trials.

Authors:  F Khosrow-Khavar; K B Filion; S Al-Qurashi; N Torabi; N Bouganim; S Suissa; L Azoulay
Journal:  Ann Oncol       Date:  2017-03-01       Impact factor: 32.976

7.  Combination therapy with tamoxifen and amphotericin B in experimental cutaneous leishmaniasis.

Authors:  Cristiana T Trinconi; Juliana Q Reimão; Jenicer K U Yokoyama-Yasunaka; Danilo C Miguel; Silvia R B Uliana
Journal:  Antimicrob Agents Chemother       Date:  2014-02-18       Impact factor: 5.191

8.  Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?

Authors:  H Wiseman; G Paganga; C Rice-Evans; B Halliwell
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

9.  Selective Estrogen Receptor Modulators Limit Alphavirus Infection by Targeting the Viral Capping Enzyme nsP1.

Authors:  Rajat Mudgal; Chandrima Bharadwaj; Aakriti Dubey; Shweta Choudhary; Perumal Nagarajan; Megha Aggarwal; Yashika Ratra; Soumen Basak; Shailly Tomar
Journal:  Antimicrob Agents Chemother       Date:  2022-01-18       Impact factor: 5.938

10.  Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines.

Authors:  C Ferlini; G Scambia; M Marone; M Distefano; C Gaggini; G Ferrandina; A Fattorossi; G Isola; P Benedetti Panici; S Mancuso
Journal:  Br J Cancer       Date:  1999-01       Impact factor: 7.640
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