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Literature DB >> 23350651

Synthesis of long T₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging.

Tonya M Atkins¹, Maja C Cassidy, Menyoung Lee, Shreyashi Ganguly, Charles M Marcus, Susan M Kauzlarich.

Abstract

We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na₄Si₄) and silicon tetrachloride (SiCl₄) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted ²⁹Si spin-lattice relaxation (T₁) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

Entities: Chemical Disease Species

Mesh：

Substances：
Isotopes
Silicon

Year: 2013 PMID： 23350651 PMCID： PMC3612549 DOI： 10.1021/nn305462y

Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881

33 in total

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Journal: Nat Nanotechnol Date: 2008-03-02 Impact factor: 39.213

2. Dynamic nuclear polarization in silicon microparticles.

Authors: A E Dementyev; D G Cory; C Ramanathan
Journal: Phys Rev Lett Date: 2008-03-24 Impact factor: 9.161

3. A liquid-solution-phase synthesis of crystalline silicon.

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Journal: Science Date: 1992-11-13 Impact factor: 47.728

Review 4. Multimodality imaging probes: design and challenges.

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Journal: Chem Rev Date: 2010-05-12 Impact factor: 60.622

5. Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.

Authors: Patrick C A van der Wel; Kan-Nian Hu; Józef Lewandowski; Robert G Griffin
Journal: J Am Chem Soc Date: 2006-08-23 Impact factor: 15.419

6. Development of iron-doped silicon nanoparticles as bimodal imaging agents.

Authors: Mani P Singh; Tonya M Atkins; Elayaraja Muthuswamy; Saeed Kamali; Chuqiao Tu; Angelique Y Louie; Susan M Kauzlarich
Journal: ACS Nano Date: 2012-05-29 Impact factor: 15.881

7. Biodegradable luminescent porous silicon nanoparticles for in vivo applications.

Authors: Ji-Ho Park; Luo Gu; Geoffrey von Maltzahn; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Journal: Nat Mater Date: 2009-02-22 Impact factor: 43.841

8. A versatile low temperature synthetic route to Zintl phase precursors: Na4Si4, Na4Ge4 and K4Ge4 as examples.

Authors: Xuchu Ma; Fen Xu; Tonya M Atkins; Andrea M Goforth; Doinita Neiner; Alexandra Navrotsky; Susan M Kauzlarich
Journal: Dalton Trans Date: 2009-10-16 Impact factor: 4.390

9. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Authors: Sam E Day; Mikko I Kettunen; Ferdia A Gallagher; De-En Hu; Mathilde Lerche; Jan Wolber; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Kevin M Brindle
Journal: Nat Med Date: 2007-10-28 Impact factor: 53.440

10. Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic.

Authors: Haiyuan Zhang; Darren R Dunphy; Xingmao Jiang; Huan Meng; Bingbing Sun; Derrick Tarn; Min Xue; Xiang Wang; Sijie Lin; Zhaoxia Ji; Ruibin Li; Fred L Garcia; Jing Yang; Martin L Kirk; Tian Xia; Jeffrey I Zink; Andre Nel; C Jeffrey Brinker
Journal: J Am Chem Soc Date: 2012-09-17 Impact factor: 15.419

16 in total

Synthesis of long T₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging.

1. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications.

2. Dynamic nuclear polarization in silicon microparticles.

3. A liquid-solution-phase synthesis of crystalline silicon.

Review 4. Multimodality imaging probes: design and challenges.

5. Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.

6. Development of iron-doped silicon nanoparticles as bimodal imaging agents.

7. Biodegradable luminescent porous silicon nanoparticles for in vivo applications.

8. A versatile low temperature synthetic route to Zintl phase precursors: Na4Si4, Na4Ge4 and K4Ge4 as examples.

9. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

10. Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic.

Review 1. Vascular targeting of nanoparticles for molecular imaging of diseased endothelium.

2. A method for imaging and spectroscopy using γ-rays and magnetic resonance.

Review 3. Targeted nanotechnology for cancer imaging.

Review 4. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

5. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer.

6. In vivo magnetic resonance imaging of hyperpolarized silicon particles.

7. Investigating the effects of vacancies on self-diffusion in silicon clusters using classical molecular dynamics.

8. Synthesis of PEG-grafted boron doped Si nanocrystals.

9. Dynamic Nuclear Polarization of Silicon Carbide Micro- and Nanoparticles.

10. Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles.