Literature DB >> 2335014

Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation.

M Hirose1, K Wakabayashi, S Grivas, S De Flora, N Arakawa, M Nagao, T Sugimura.   

Abstract

A direct-acting mutagen to Salmonella typhimurium TA98 was found to be formed by exposing 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in acetone to sunlight for 60 min. The direct-acting mutagen in the irradiated sample was purified by HPLC and identified as 3,4-dimethyl-2-nitroimidazo-[4,5-f]quinoline (NO2-MeIQ). The yield of NO2-MeIQ from MeIQ was estimated to be 0.3%.

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Year:  1990        PMID: 2335014     DOI: 10.1093/carcin/11.5.869

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN: 0143-3334            Impact factor:   4.944


  1 in total

1.  Prostaglandin-H synthase mediated metabolism and mutagenic activation of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ).

Authors:  E Wolz; D Wild; G H Degen
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

  1 in total

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