Literature DB >> 23349115

Pesticides, microglial NOX2, and Parkinson's disease.

Thomas Taetzsch1, Michelle L Block.   

Abstract

Accumulating evidence indicates that pesticide exposure is associated with an increased risk for developing Parkinson's disease (PD). Several pesticides known to damage dopaminergic (DA) neurons, such as paraquat, rotenone, lindane, and dieldrin also demonstrate the ability to activate microglia, the resident innate immune cell in the brain. While each of these environmental toxicants may impact microglia through unique mechanisms, they all appear to converge on a common final pathway of microglial activation: NADPH oxidase 2 (NOX2) activation. This review will detail the role of microglia in selective DA neurotoxicity, highlight what is currently known about the mechanism of microglial NOX2 activation in these key pesticides, and describe the importance for DA neuron survival and PD etiology.
© 2013 Wiley Periodicals, Inc.

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Year:  2013        PMID： 23349115      PMCID： PMC3953497          DOI： 10.1002/jbt.21464

Source DB:  PubMed          Journal:  J Biochem Mol Toxicol        ISSN： 1095-6670            Impact factor:   3.642


  171 in total

Review 1.  The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis.

Authors:  Ulf T Brunk; Alexei Terman
Journal:  Eur J Biochem       Date:  2002-04

2.  Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3.

Authors:  Phillip M Rappold; Mei Cui; Adrianne S Chesser; Jacqueline Tibbett; Jonathan C Grima; Lihua Duan; Namita Sen; Jonathan A Javitch; Kim Tieu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

3.  Migration and differentiation of neural precursor cells can be directed by microglia.

Authors:  Johan Aarum; Kristian Sandberg; Samantha L Budd Haeberlein; Mats A A Persson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-10       Impact factor: 11.205

4.  MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity.

Authors:  Zhong Pei; Hao Pang; Li Qian; Sufen Yang; Tonggauang Wang; Wei Zhang; Xeufei Wu; Shannon Dallas; Belinda Wilson; Jeffrey M Reece; David S Miller; Jau-Shyong Hong; Michelle L Block
Journal:  Glia       Date:  2007-10       Impact factor: 7.452

5.  Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways.

Authors:  Emily N Mangano; Darcy Litteljohn; Remmick So; Eric Nelson; Sarah Peters; Cheri Bethune; Jessica Bobyn; Shawn Hayley
Journal:  Neurobiol Aging       Date:  2011-04-11       Impact factor: 4.673

6.  Environmental risk factors and Parkinson's disease: a case-control study in Taiwan.

Authors:  H H Liou; M C Tsai; C J Chen; J S Jeng; Y C Chang; S Y Chen; R C Chen
Journal:  Neurology       Date:  1997-06       Impact factor: 9.910

7.  Selective effects of insecticides on nigrostriatal dopaminergic nerve pathways.

Authors:  Jeffrey R Bloomquist; Rebecca L Barlow; Jeffrey S Gillette; Wen Li; Michael L Kirby
Journal:  Neurotoxicology       Date:  2002-10       Impact factor: 4.294

8.  Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

Authors:  Wei Zhang; Shannon Dallas; Dan Zhang; Jian-Ping Guo; Hao Pang; Belinda Wilson; David S Miller; Biao Chen; Wanqin Zhang; Patrick L McGeer; Jau-Shyong Hong; Jing Zhang
Journal:  Glia       Date:  2007-08-15       Impact factor: 7.452

9.  Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study.

Authors:  Aiste Jekabsone; Palwinder K Mander; Anna Tickler; Martyn Sharpe; Guy C Brown
Journal:  J Neuroinflammation       Date:  2006-09-07       Impact factor: 8.322

10.  Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.

Authors:  Fang Zhou; Hong-Hong Yao; Jia-Yong Wu; Jian-Hua Ding; Tao Sun; Gang Hu
Journal:  J Cell Mol Med       Date:  2008 Sep-Oct       Impact factor: 5.310
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  24 in total

Review 1.  New insights on NOX enzymes in the central nervous system.

Authors:  Zeynab Nayernia; Vincent Jaquet; Karl-Heinz Krause
Journal:  Antioxid Redox Signal       Date:  2014-01-16       Impact factor: 8.401

Review 2.  Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public.

Authors:  Seema Patel; Sushree Sangeeta
Journal:  Environ Sci Pollut Res Int       Date:  2018-11-08       Impact factor: 4.223

Review 3.  Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms.

Authors:  Arthi Kanthasamy; Huajun Jin; Adhithiya Charli; Anantharam Vellareddy; Anumantha Kanthasamy
Journal:  Pharmacol Ther       Date:  2019-01-22       Impact factor: 12.310

4.  Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase A2/arachidonic acid.

Authors:  Lee C Mangum; Abdolsamad Borazjani; John V Stokes; Anberitha T Matthews; Jung Hwa Lee; Janice E Chambers; Matthew K Ross
Journal:  Chem Res Toxicol       Date:  2015-02-11       Impact factor: 3.739

Review 5.  Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.

Authors:  Annadurai Anandhan; Maria S Jacome; Shulei Lei; Pablo Hernandez-Franco; Aglaia Pappa; Mihalis I Panayiotidis; Robert Powers; Rodrigo Franco
Journal:  Brain Res Bull       Date:  2017-03-21       Impact factor: 4.077

6.  Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model.

Authors:  Yan-Hua Li; Qing He; Jie-zhong Yu; Chun-yun Liu; Ling Feng; Zhi Chai; Qing Wang; Hong-zhen Zhang; Guang-Xian Zhang; Bao-guo Xiao; Cun-gen Ma
Journal:  Metab Brain Dis       Date:  2015-06-19       Impact factor: 3.584

7.  Monte Carlo cross-validation analysis screens pathway cross-talk associated with Parkinson's disease.

Authors:  Tianrong Li; Weidong Tang; Li Zhang
Journal:  Neurol Sci       Date:  2016-05-04       Impact factor: 3.307

8.  Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.

Authors:  Qian Zhou; Chunxiao Liu; Wen Liu; Hai Zhang; Ruijie Zhang; Jia Liu; Jinfei Zhang; Chong Xu; Lei Liu; Shile Huang; Long Chen
Journal:  Toxicol Sci       Date:  2014-10-09       Impact factor: 4.849

Review 9.  Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease.

Authors:  Md Zeeshan Rasheed; Heena Tabassum; Suhel Parvez
Journal:  Protoplasma       Date:  2016-01-29       Impact factor: 3.356

Review 10.  Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease.

Authors:  Xiao-Feng Zhang; Mark Thompson; Yi-Hua Xu
Journal:  Lab Invest       Date:  2016-02-01       Impact factor: 5.662
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