| Literature DB >> 23348703 |
Xuan Wang1, Kun Wang, Lei Han, Anling Zhang, Zhendong Shi, Kailiang Zhang, Hongwei Zhang, Shaohua Yang, Peiyu Pu, Changhong Shen, Chunjiang Yu, Chunsheng Kang.
Abstract
The transcriptional regulator PRDM1 controls cell-fate decisions and has been implicated in human tumorigenesis as a tumor suppressor. However, its pathological role in glioma remains elusive. In this study, we showed that PRDM1 protein levels were inversely correlated with the pathological grade of gliomas and were predictive of patient survival in a retrospective analysis. Restored expression of PRDM1 inhibited proliferation and suppressed invasion by glioma cells. Mechanistic investigation revealed that PRDM1 attenuated glioma malignancy by negatively modulating Wnt/β-catenin signaling and this modulation was dependent on the Wnt inhibitor Dkk1. Using bioinformatics and biological approaches, we found that PRDM1 was a direct target of miR-30a-5p, and PRDM1 dysfunction was attributable to miR-30a-5p-mediated repression. Our results provide evidence that PRDM1 deficiency contributes to the phenotype maintenance and pathogenesis of gliomas.Entities:
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Year: 2013 PMID： 23348703 DOI： 10.1016/j.canlet.2013.01.005
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679