Literature DB >> 23347137

Binge ethanol and liver: new molecular developments.

Shivendra D Shukla1, Stephen B Pruett, Gyongyi Szabo, Gavin E Arteel.   

Abstract

Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.
Copyright © 2013 by the Research Society on Alcoholism.

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Year:  2013        PMID： 23347137      PMCID： PMC4831914          DOI： 10.1111/acer.12011

Source DB:  PubMed          Journal:  Alcohol Clin Exp Res        ISSN： 0145-6008            Impact factor:   3.455


  54 in total

1.  Nimodipine, a dihydropyridine-type calcium channel blocker, prevents alcoholic hepatitis caused by chronic intragastric ethanol exposure in the rat.

Authors:  Y Iimuro; K Ikejima; M L Rose; B U Bradford; R G Thurman
Journal:  Hepatology       Date:  1996-08       Impact factor: 17.425

2.  Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol.

Authors:  E J Carson; S B Pruett
Journal:  Alcohol Clin Exp Res       Date:  1996-02       Impact factor: 3.455

3.  In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation.

Authors:  Joanna Goral; Elizabeth J Kovacs
Journal:  J Immunol       Date:  2005-01-01       Impact factor: 5.422

4.  Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver.

Authors:  N Enomoto; K Ikejima; S Yamashina; A Enomoto; T Nishiura; T Nishimura; D A Brenner; P Schemmer; B U Bradford; C A Rivera; Z Zhong; R G Thurman
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-07       Impact factor: 4.052

Review 5.  Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.

Authors:  Patricia E Ganey; James P Luyendyk; Jane F Maddox; Robert A Roth
Journal:  Chem Biol Interact       Date:  2004-11-01       Impact factor: 5.192

Review 6.  The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury.

Authors:  R G Thurman; B U Bradford; Y Iimuro; K T Knecht; G E Arteel; M Yin; H D Connor; C Wall; J A Raleigh; M V Frankenberg; Y Adachi; D T Forman; D Brenner; M Kadiiska; R P Mason
Journal:  J Gastroenterol Hepatol       Date:  1998-09       Impact factor: 4.029

7.  Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells.

Authors:  G E Arteel; J A Raleigh; B U Bradford; R G Thurman
Journal:  Am J Physiol       Date:  1996-09

Review 8.  Signalling pathways in alcohol-induced liver inflammation.

Authors:  Pranoti Mandrekar; Gyongyi Szabo
Journal:  J Hepatol       Date:  2009-03-28       Impact factor: 25.083

9.  Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice.

Authors:  Hu-Quan Yin; Mingoo Kim; Ju-Han Kim; Gu Kong; Kyung-Sun Kang; Hyung-Lae Kim; Byung-Il Yoon; Mi-Ock Lee; Byung-Hoon Lee
Journal:  Toxicol Appl Pharmacol       Date:  2007-07-04       Impact factor: 4.219

10.  Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo.

Authors:  G E Arteel; Y Iimuro; M Yin; J A Raleigh; R G Thurman
Journal:  Hepatology       Date:  1997-04       Impact factor: 17.425
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  30 in total

Review 1.  Binge drinking: Burden of liver disease and beyond.

Authors:  Susana Llerena; María Teresa Arias-Loste; Angela Puente; Joaquín Cabezas; Javier Crespo; Emilio Fábrega
Journal:  World J Hepatol       Date:  2015-11-28

2.  Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration.

Authors:  Stephanie Mathews; Dechun Feng; Igor Maricic; Cynthia Ju; Vipin Kumar; Bin Gao
Journal:  Cell Mol Immunol       Date:  2015-02-09       Impact factor: 11.530

3.  Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles.

Authors:  Shivendra D Shukla; Ricardo Restrepo; Annayya R Aroor; Xuanyou Liu; Robert W Lim; Jacob D Franke; David A Ford; Ronald J Korthuis
Journal:  J Pharmacol Exp Ther       Date:  2019-07-01       Impact factor: 4.030

4.  Blood alcohol content, injury severity, and adult respiratory distress syndrome.

Authors:  Majid Afshar; Gordon S Smith; Michael L Terrin; Matthew Barrett; Matthew E Lissauer; Sahar Mansoor; Jean Jeudy; Giora Netzer
Journal:  J Trauma Acute Care Surg       Date:  2014-06       Impact factor: 3.313

5.  Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans.

Authors:  Jun-Won Yun; Min-Jeong Son; Mohamed A Abdelmegeed; Atrayee Banerjee; Timothy R Morgan; Seong-Ho Yoo; Byoung-Joon Song
Journal:  Free Radic Biol Med       Date:  2014-09-16       Impact factor: 7.376

6.  Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice.

Authors:  Terence N Bukong; Arvin Iracheta-Vellve; Benedek Gyongyosi; Aditya Ambade; Donna Catalano; Karen Kodys; Gyongyi Szabo
Journal:  Alcohol Clin Exp Res       Date:  2016-05-14       Impact factor: 3.455

7.  ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis.

Authors:  Wen-Wei Tsai; Shigenobu Matsumura; Weiyi Liu; Naomi G Phillips; Tim Sonntag; Ergeng Hao; Soon Lee; Tsonwin Hai; Marc Montminy
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-17       Impact factor: 11.205

8.  Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity.

Authors:  Hong-Min Ni; Kuo Du; Min You; Wen-Xing Ding
Journal:  Am J Pathol       Date:  2013-10-01       Impact factor: 4.307

9.  Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice.

Authors:  Jessica A Williams; Hong-Min Ni; Yifeng Ding; Wen-Xing Ding
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2015-07-09       Impact factor: 4.052

10.  Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure.

Authors:  Anny Gano; Tamara L Doremus-Fitzwater; Terrence Deak
Journal:  Brain Res       Date:  2016-05-18       Impact factor: 3.252
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