Literature DB >> 23345920

Survival chances of mutants starting with one individual.

Christoph Kuhn1.   

Abstract

UNLABELLED: A simple theoretical model of a Darwinian system (a periodic system with a multiplication phase and a selection phase) of entities (initial form of polymer strand, primary mutant and satellite mutants) is given. FIRST CASE: one mutant is considered. One individual of the mutant appears in the multiplication phase of the first generation. The probabilities to find N mutants W(n) (M)(N) after the multiplication phase M of the n-th generation (with probability δ of an error in the replication, where all possible errors are fatal errors) and W(n) (S)(N) after the following selection phase S (with probability β that one individual survives) are given iteratively. The evolutionary tree is evaluated. Averages from the distributions and the probability of extinction W(∞) (S)(0) are obtained.Second case: two mutants are considered (primary mutant and new form). One individual of the primary mutant appears in the multiplication phase of the first generation. The probabilities to find N(p) primary mutants and N(m) of the new form W(n) (M)(N(p), N(m)) after the multiplication phase M of the n-th generation (probability ε of an error in the replication of the primary mutant giving the new form) and W(n) (S)(N(p), N(m)) after the following selection phase S (probabilities β(p) and β(m) that one individual each of the primary mutant and of the new form survives) are given iteratively. Again the evolutionary tree is evaluated. Averages from the distributions are obtained.

Entities:  

Keywords:  Bernoulli polynomial; Darwinian system; complementary and anti-parallel replication; error in replication; evolutionary tree; initial form; minus-strand; multiplication; origin of life; plus-strand; primary mutant; probability distribution; satellite mutants; selection; translation apparatus

Year:  2005        PMID: 23345920      PMCID: PMC3456339          DOI: 10.1007/s10867-005-6061-9

Source DB:  PubMed          Journal:  J Biol Phys        ISSN: 0092-0606            Impact factor:   1.365


  2 in total

1.  Computer-modeling origin of a simple genetic apparatus.

Authors:  C Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 2.  Diversified world: drive to life's origin?!

Authors:  Hans Kuhn; Christoph Kuhn
Journal:  Angew Chem Int Ed Engl       Date:  2003-01-20       Impact factor: 15.336

  2 in total
  1 in total

1.  Immune response to a variable pathogen: a stochastic model with two interlocked Darwinian entities.

Authors:  Christoph Kuhn
Journal:  Comput Math Methods Med       Date:  2012-12-02       Impact factor: 2.238

  1 in total

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