| Literature DB >> 23345702 |
Abstract
The SOS response in Escherichia coli is induced after DNA-damaging treatments including ultraviolet light. Regulation of the SOS response is accomplished through specific interaction of the two SOS regulator proteins, LexA and RecA. In ultraviolet light-treated cells, nucleotide excision repair is the major system that removes the induced lesions from the DNA. Here, induction of the SOS response in Escherichia coli with normal and impaired excision repair function is studied by simulation of intracellular levels of regulatory LexA and RecA proteins, and SulA protein. SulA protein is responsible for SOS-inducible cell division inhibition. Results of the simulations show that nucleotide excision repair influences time-courses of LexA, RecA and SulA induction by modulating the dynamics of RecA protein distribution between its normal and SOS-activated forms.Entities:
Keywords: Escherichia coli; Inducing signal; LexA; Nucleotide excision repair; RecA; SOS response; SulA; Ultravioletlight
Year: 1999 PMID： 23345702 PMCID： PMC3455958 DOI： 10.1023/A:1005163310168
Source DB: PubMed Journal: J Biol Phys ISSN： 0092-0606 Impact factor: 1.365