Giovanna Spatari1, Salvatore Saitta2, Concetto Giorgianni1, Maria Teresa Cristani3, Paolina Quattrocchi4, Adriana Abbate1, Mariella Carrieri5, Giorgia Ferraro6, Antonella Saija3, Sebastiano Gangemi7. 1. Department of Social and Environmental Medicine, University of Messina, Messina, Italy. 2. Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Messina, Italy saittasalvatore@tiscalinet.it. 3. Department Farmaco-Biologico, School of Pharmacy, University of Messina, Messina, Italy. 4. Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Messina, Italy. 5. Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy. 6. Department of Clinical and Experimental Medicine, Fellow unit of Allergy and Clinical Immunology, University of Messina, Messina, Italy. 7. Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Messina, Italy Institute of Biomedicine and Molecular Immunology, National Research Council, Palermo, Italy.
Abstract
OBJECTIVE: To establish if serum levels of interleukin-10 (IL-10) in subjects exposed to benzene are connected with age, working years, and employment age. METHODS: We evaluated serum levels of IL-10 in 51 employees working in oil refinery (group A) and in 16 office workers who resided in the same area (group B). RESULTS: There was no statistically significant difference between serum concentrations of IL-10 in groups A and B. There was a statistically significant dependent relationship in group A between age, working years, and serum concentration of IL-10. There was a statistically significant and positive dependent relationship in group A between serum concentration of IL-10 and employment age. CONCLUSIONS: The role played by IL-10 in benzene immune suppression may be relevant and attention should be directed toward assessment of age, working years, and employment age in benzene-exposed populations.
OBJECTIVE: To establish if serum levels of interleukin-10 (IL-10) in subjects exposed to benzene are connected with age, working years, and employment age. METHODS: We evaluated serum levels of IL-10 in 51 employees working in oil refinery (group A) and in 16 office workers who resided in the same area (group B). RESULTS: There was no statistically significant difference between serum concentrations of IL-10 in groups A and B. There was a statistically significant dependent relationship in group A between age, working years, and serum concentration of IL-10. There was a statistically significant and positive dependent relationship in group A between serum concentration of IL-10 and employment age. CONCLUSIONS: The role played by IL-10 in benzene immune suppression may be relevant and attention should be directed toward assessment of age, working years, and employment age in benzene-exposed populations.