| Literature DB >> 23343665 |
Frances M Velez-Lago1, Amanda Thompson, Genko Oyama, Angela Hardwick, Justin M Sporrer, Pamela Zeilman, Kelly D Foote, Dawn Bowers, Herbert E Ward, Juan Sanchez-Ramos, Michael S Okun.
Abstract
Huntington's disease (HD) is an autosomal dominant and progressive neurodegenerative syndrome characterized by motor, cognitive and psychiatric manifestations. Chorea and dystonia are features that may be troublesome to some patients and may potentially prove unresponsive to pharmacological treatments. There are several reports on the results of globus pallidus internus deep brain stimulation (DBS) surgery for HD. In these published cases, DBS was utilized mainly to treat disabling chorea. We report our experience with 2 HD cases treated with DBS. The cases illustrate a differential response with a better outcome in the choreic presentation compared to the dystonic presentation. Additionally, DBS worsened gait features in both cases.Entities:
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Year: 2013 PMID： 23343665 DOI： 10.1159/000341070
Source DB: PubMed Journal: Stereotact Funct Neurosurg ISSN： 1011-6125 Impact factor: 1.875