Literature DB >> 2334163

Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus.

Y Sumita1, M Fukasawa, T Okuda.   

Abstract

SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 microgram/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

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Year:  1990        PMID： 2334163      PMCID： PMC171622          DOI： 10.1128/AAC.34.3.484

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Multicenter in vitro evaluation of SM-7338, a new carbapenem.

Authors:  R N Jones; K E Aldridge; S D Allen; A L Barry; P C Fuchs; E H Gerlach; M A Pfaller
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

2.  In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.

Authors:  H C Neu; A Novelli; N X Chin
Journal:  Antimicrob Agents Chemother       Date:  1989-07       Impact factor: 5.191

Review 3.  Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

Authors:  P M Blumberg; J L Strominger
Journal:  Bacteriol Rev       Date:  1974-09

4.  A novel character of acylaminobenzylpenicillin apalcillin, in binding to penicillin-binding proteins of Escherichia coli and Pseudomonas aeruginosa.

Authors:  M Fukasawa; H Noguchi; S Mitsuhashi; F Ishino; M Matsuhashi; T Komatsu
Journal:  J Antibiot (Tokyo)       Date:  1984-03       Impact factor: 2.649

5.  Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.

Authors:  H Suginaka; P M Blumberg; J L Strominger
Journal:  J Biol Chem       Date:  1972-09-10       Impact factor: 5.157

6.  Comparative in vitro activity of SM7338, a new carbapenem antimicrobial agent.

Authors:  D E Sentochnik; G M Eliopoulos; M J Ferraro; R C Moellering
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

7.  Possible physiological functions of penicillin-binding proteins in Staphylococcus aureus.

Authors:  N H Georgopapadakou; B A Dix; Y R Mauriz
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

8.  Occurrence of a beta-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci.

Authors:  K Ubukata; N Yamashita; M Konno
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

9.  Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus.

Authors:  Y Utsui; T Yokota
Journal:  Antimicrob Agents Chemother       Date:  1985-09       Impact factor: 5.191

10.  In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I.

Authors:  J R Edwards; P J Turner; C Wannop; E S Withnell; A J Grindey; K Nairn
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191
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  11 in total

Review 1.  Comparative pharmacokinetics of the carbapenems: clinical implications.

Authors:  J W Mouton; D J Touzw; A M Horrevorts; A A Vinks
Journal:  Clin Pharmacokinet       Date:  2000-09       Impact factor: 6.447

2.  In vitro synergistic activity between meropenem and other beta-lactams against methicillin-resistant Staphylococcus aureus.

Authors:  Y Sumita; S Mitsuhashi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

3.  Transcription analysis of the Staphylococcus aureus gene encoding penicillin-binding protein 4.

Authors:  T L Domanski; B L de Jonge; K W Bayles
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

4.  In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria.

Authors:  Evelyne Lacasse; Eric Brouillette; Audrey Larose; Thomas R Parr; Aileen Rubio; François Malouin
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

5.  Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects.

Authors:  G G Zhanel; A E Simor; L Vercaigne; L Mandell
Journal:  Can J Infect Dis       Date:  1998-07

6.  Characterization of penicillin-binding protein 2 of Staphylococcus aureus: deacylation reaction and identification of two penicillin-binding peptides.

Authors:  H F Chambers; C Miick
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191

7.  Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus.

Authors:  H F Chambers; M J Sachdeva; C J Hackbarth
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

Review 8.  Meropenem clinical pharmacokinetics.

Authors:  J W Mouton; J N van den Anker
Journal:  Clin Pharmacokinet       Date:  1995-04       Impact factor: 6.447

Review 9.  Meropenem. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.

Authors:  L R Wiseman; A J Wagstaff; R N Brogden; H M Bryson
Journal:  Drugs       Date:  1995-07       Impact factor: 9.546

10.  Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus.

Authors:  Y Sumita; H Nouda; K Kanazawa; M Fukasawa
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191
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