Literature DB >> 2334160

Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.

I Fourel1, O Hantz, K A Watanabe, C Jacquet, B Chomel, J J Fox, C Trepo.   

Abstract

The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.

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Year:  1990        PMID： 2334160      PMCID： PMC171618          DOI： 10.1128/AAC.34.3.473

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  The molecular biology of the hepatitis B viruses.

Authors:  D Ganem; H E Varmus
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

2.  Inhibition of human and woodchuck hepatitis virus DNA polymerase by the triphosphates of acyclovir, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and E-5-(2-bromovinyl)-2'-deoxyuridine.

Authors:  O Hantz; H S Allaudeen; T Ooka; E De Clercq; C Trepo
Journal:  Antiviral Res       Date:  1984-08       Impact factor: 5.970

Review 3.  Taxonomic classification of human hepatitis B virus.

Authors:  I D Gust; C J Burrell; A G Coulepis; W S Robinson; A J Zuckerman
Journal:  Intervirology       Date:  1986       Impact factor: 1.763

4.  Pilot study of recombinant human alpha-interferon for chronic type B hepatitis.

Authors:  J S Dooley; G L Davis; M Peters; J G Waggoner; Z Goodman; J H Hoofnagle
Journal:  Gastroenterology       Date:  1986-01       Impact factor: 22.682

5.  Effects of adenine arabinoside on serum and intrahepatic replicative forms of duck hepatitis B virus in chronic infection.

Authors:  K Hirota; A H Sherker; M Omata; O Yokosuka; K Okuda
Journal:  Hepatology       Date:  1987 Jan-Feb       Impact factor: 17.425

6.  Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies.

Authors:  P S Venkateswaran; I Millman; B S Blumberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

7.  Comparative study of DHBV DNA levels and endogenous DNA polymerase activity in naturally infected ducklings in France.

Authors:  L Cova; O Hantz; M Arliaud-Gassin; A Chevalier; P Berthillon; J Boulay; C Jacquet; B Chomel; L Vitvitski; C Trepo
Journal:  J Virol Methods       Date:  1985-03       Impact factor: 2.014

8.  Therapeutic activity of vidarabine in symptomatic chronic active hepatitis related to HBV.

Authors:  C Trépo; D Ouzan; T Fontanges; M Chevallier; P Chossegros; F Degos; P Chevallier; O Hantz
Journal:  J Hepatol       Date:  1986       Impact factor: 25.083

9.  Therapeutic potential of acyclovir and of the interferons in HBV-related chronic active hepatitis due to HBV with or without HDV superinfection.

Authors:  C Trépo; D Ouzan; T Fontanges; M Chevallier; P Chossegros; F Degos; P Chevallier; O Hantz
Journal:  J Hepatol       Date:  1986       Impact factor: 25.083

10.  Foscarnet decreases serum and liver duck hepatitis B virus DNA in chronically infected ducks.

Authors:  A H Sherker; K Hirota; M Omata; K Okuda
Journal:  Gastroenterology       Date:  1986-10       Impact factor: 22.682
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  13 in total

Review 1.  Mitochondrial injury. Lessons from the fialuridine trial.

Authors:  P Honkoop; H R Scholte; R A de Man; S W Schalm
Journal:  Drug Saf       Date:  1997-07       Impact factor: 5.606

Review 2.  The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection.

Authors:  Stephan Menne; Paul J Cote
Journal:  World J Gastroenterol       Date:  2007-01-07       Impact factor: 5.742

3.  Comparative inhibition of hepatitis B virus DNA polymerase and cellular DNA polymerases by triphosphates of sugar-modified 5-methyldeoxycytidines and of other nucleoside analogs.

Authors:  E Matthes; K Reimer; M von Janta-Lipinski; H Meisel; C Lehmann
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

4.  Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B.

Authors:  Tomasz I Michalak; Hong Zhang; Norma D Churchill; Torbjörn Larsson; Nils-Gunnar Johansson; Bo Oberg
Journal:  Antimicrob Agents Chemother       Date:  2009-06-29       Impact factor: 5.191

5.  Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis.

Authors:  J L Martin; C E Brown; N Matthews-Davis; J E Reardon
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191

6.  Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.

Authors:  P Rajagopalan; F D Boudinot; C K Chu; B C Tennant; B H Baldwin; R F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

7.  Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.

Authors:  K Y Hostetler; J R Beadle; W E Hornbuckle; C A Bellezza; I A Tochkov; P J Cote; J L Gerin; B E Korba; B C Tennant
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

8.  In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks.

Authors:  J M Cullen; S L Smith; M G Davis; S E Dunn; C Botteron; A Cecchi; D Linsey; D Linzey; L Frick; M T Paff; A Goulding; K Biron
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

9.  Inhibition of episomal hepatitis B virus DNA in vitro by 2,4-diamino-7- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-pyrrolo[2,3-d]pyrimidine.

Authors:  J O Ojwang; B K Bhattacharya; H B Marshall; B E Korba; G R Revankar; R F Rando
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

10.  Sensitive and specific radioimmunoassay for fialuridine: initial assessment of pharmacokinetics after single oral doses to healthy volunteers.

Authors:  R R Bowsher; J A Compton; J A Kirkwood; G D Place; C D Jones; T E Mabry; D L Hyslop; B L Hatcher; K A DeSante
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191
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