BACKGROUND: The purpose was to estimate the incidence and characteristics of childhood inflammatory bowel disease (IBD) during 2000-2010 in Shanghai, China. METHODS: IBD patients between the ages of 0 and 18 years old were identified by survey of computerized medical information. Relevant data were extracted from their corresponding medical records. RESULTS: A total of 153 IBD cases were included in the study. Among them, 107 were males and 46 were females (male/female ratio, 2.3:1.0). Eighty-two had Crohn's disease (CD) and 71 had ulcerative colitis (UC). The peak prevalence of IBD was observed in the 10-14-year-old age group. The annual incidence of IBD in the 0 to 14 years age group of Shanghai residents steadily increased from 2000 to 2010. The most common symptoms of IBD were diarrhea (68.6%), bloody stool (68.6%), and abdominal pain (61.4%). More CD than UC patients had anemia and raised erythrocyte sedimentation rate and C-reactive protein levels. Ileocolonic type disease was more common in CD patients, and left-side colon involvement was more common in UC. Of all CD patients, 33 had mild active disease and 49 had moderate/severe disease. In UC patients, 34 were mild and 37 were moderate/severe disease. CONCLUSIONS: This retrospective, multicenter hospital-based study over a decade shows a steadily increasing trend of childhood IBD in China. This suggests a need for population-based epidemiological studies to explore the risk factors.
BACKGROUND: The purpose was to estimate the incidence and characteristics of childhood inflammatory bowel disease (IBD) during 2000-2010 in Shanghai, China. METHODS: IBD patients between the ages of 0 and 18 years old were identified by survey of computerized medical information. Relevant data were extracted from their corresponding medical records. RESULTS: A total of 153 IBD cases were included in the study. Among them, 107 were males and 46 were females (male/female ratio, 2.3:1.0). Eighty-two had Crohn's disease (CD) and 71 had ulcerative colitis (UC). The peak prevalence of IBD was observed in the 10-14-year-old age group. The annual incidence of IBD in the 0 to 14 years age group of Shanghai residents steadily increased from 2000 to 2010. The most common symptoms of IBD were diarrhea (68.6%), bloody stool (68.6%), and abdominal pain (61.4%). More CD than UC patients had anemia and raised erythrocyte sedimentation rate and C-reactive protein levels. Ileocolonic type disease was more common in CDpatients, and left-side colon involvement was more common in UC. Of all CDpatients, 33 had mild active disease and 49 had moderate/severe disease. In UC patients, 34 were mild and 37 were moderate/severe disease. CONCLUSIONS: This retrospective, multicenter hospital-based study over a decade shows a steadily increasing trend of childhood IBD in China. This suggests a need for population-based epidemiological studies to explore the risk factors.
Authors: Mohammad Issa El Mouzan; Mohammed Hadi Al Edreesi; Abdulrahman Abdullah Al-Hussaini; Omar Ibrahim Saadah; Abdulaziz Abdullatif Al Qourain; Mohammad Abdullah Al Mofarreh; Khalid Abdulrahman Al Saleem Journal: World J Gastroenterol Date: 2016-02-07 Impact factor: 5.742
Authors: Peiqi Wang; Jun Hu; Shadi Ghadermarzi; Ali Raza; Douglas O'Connell; Amy Xiao; Faraz Ayyaz; Min Zhi; Yuanqi Zhang; Nimisha K Parekh; Mark Lazarev; Alyssa Parian; Steven R Brant; Marshall Bedine; Brindusa Truta; Pinjin Hu; Rupa Banerjee; Susan M Hutfless Journal: Dig Dis Sci Date: 2018-06-04 Impact factor: 3.199
Authors: Pei-Qi Wang; Jun Hu; Elie S Al Kazzi; Eboselume Akhuemonkhan; Min Zhi; Xiang Gao; Raquel Holand de Paula Pessoa; Sami Ghazaleh; Tuhina Cornelius; Suhel Abbas Sabunwala; Shadi Ghadermarzi; Kartikeya Tripathi; Mark Lazarev; Pin-Jin Hu; Susan Hutfless Journal: World J Gastrointest Pharmacol Ther Date: 2016-11-06