BACKGROUND: We report a meta-analysis of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization prevalence in children and a review of the risk factors as well as molecular genetic characterization. METHODS: All relevant studies reporting prevalence data on MRSA nasal colonization in children published between January 2000 and August 2010 were retrieved from the MEDLINE database and analyzed. RESULTS: After screening 544 studies, 50 studies were included. We obtained an estimate of MRSA prevalence of 2.7% (95% confidence interval [CI]: 2.2-3.1); of 5.2% (95% CI: 3.1-7.3) in children with underlying conditions and of 2.3% (95% CI: 1.8-2.7) in healthy children; 5.4% (95% CI: 3.1-7.7) in children recruited in hospitals and 3% (95% CI: 2.4-3.6) in children recruited in the community. Staphylococcal cassette chromosome mec type IV is the most diffused cassette globally. CONCLUSION: The hospital remains the environment where the microorganism circulates most. Children with underlying conditions could act as vectors of microorganisms between the hospital and the community. MRSA prevention strategies should be tailored to each specific institution, taking into account the nosocomial prevalence of MRSA nasal colonization and infections, and the prevalence of nasal colonization in the community that refers to the specific health care center.
BACKGROUND: We report a meta-analysis of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization prevalence in children and a review of the risk factors as well as molecular genetic characterization. METHODS: All relevant studies reporting prevalence data on MRSA nasal colonization in children published between January 2000 and August 2010 were retrieved from the MEDLINE database and analyzed. RESULTS: After screening 544 studies, 50 studies were included. We obtained an estimate of MRSA prevalence of 2.7% (95% confidence interval [CI]: 2.2-3.1); of 5.2% (95% CI: 3.1-7.3) in children with underlying conditions and of 2.3% (95% CI: 1.8-2.7) in healthy children; 5.4% (95% CI: 3.1-7.7) in children recruited in hospitals and 3% (95% CI: 2.4-3.6) in children recruited in the community. Staphylococcal cassette chromosome mec type IV is the most diffused cassette globally. CONCLUSION: The hospital remains the environment where the microorganism circulates most. Children with underlying conditions could act as vectors of microorganisms between the hospital and the community. MRSA prevention strategies should be tailored to each specific institution, taking into account the nosocomial prevalence of MRSA nasal colonization and infections, and the prevalence of nasal colonization in the community that refers to the specific health care center.
Authors: D M Geraci; C Bonura; M Giuffrè; A Aleo; L Saporito; G Graziano; R M Valenti; C Mammina Journal: Infection Date: 2014-01-22 Impact factor: 3.553
Authors: J Macher; C Gras Le Guen; A Chenouard; J M Liet; B Gaillard Le Roux; A Legrand; J Mahuet; E Launay; V Gournay; N Joram Journal: Pediatr Cardiol Date: 2016-11-14 Impact factor: 1.655
Authors: Anne Filleron; Sarah Beauregard-Birba; Thibault Mura; Fabien Aujoulat; Anne Laure Michon; Michel Rodière; Tu Anh Tran; Eric Jeziorski; Hélène Marchandin Journal: World J Pediatr Date: 2018-02-13 Impact factor: 2.764
Authors: Eneida Dias Vianna Braga; Fábio Aguiar-Alves; Maria de Fátima Nogueira de Freitas; Monique Oliveira de e Silva; Thami Valadares Correa; Robert E Snyder; Verônica Afonso de Araújo; Mariel Asbury Marlow; Lee W Riley; Sérgio Setúbal; Licínio Esmeraldo Silva; Claudete Aparecida Araújo Cardoso Journal: BMC Infect Dis Date: 2014-10-06 Impact factor: 3.090