| Literature DB >> 23340171 |
Kunming Wen1, Zhongxue Fu, Xingye Wu, Jihong Feng, Wangsheng Chen, Jiang Qian.
Abstract
Cancer stem cells (CSCs) have been implicated in multidrug resistance, a phenomenon responsible for the failure of cancer chemotherapy. However, the underlying mechanisms are still unclear. In our study, we established two oxaliplatin-resistant colorectal cancer cell lines displaying some CSCs characteristics. Oct4 overexpression was observed in these two lines. We performed Oct4 knock down by lentiviral vector-mediated specific shRNA. Knockdown increased apoptosis, decreased CSCs marker expression and weakened tumorigenicity in drug-resistant cell lines. In conclusion, we show that these events can be at least in part attributed to the STAT3/Survivin pathway.Entities:
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Year: 2013 PMID： 23340171 DOI： 10.1016/j.canlet.2013.01.009
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679