Literature DB >> 23338213

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1.

Takuya Terai1, Rie Tomiyasu, Tomoe Ota, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano, Tetsuo Nagano.   

Abstract

TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first "turn-on" fluorescent probes for UGTs.

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Year:  2013        PMID： 23338213     DOI： 10.1039/c3cc38810g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism.

Authors:  Clive Yik-Sham Chung; Jessica M Posimo; Sumin Lee; Tiffany Tsang; Julianne M Davis; Donita C Brady; Christopher J Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-26       Impact factor: 11.205

Review 2.  Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives.

Authors:  Qiang Jin; JingJing Wu; Yue Wu; Hongxin Li; Moshe Finel; Dandan Wang; Guangbo Ge
Journal:  Acta Pharm Sin B       Date:  2022-01-21       Impact factor: 14.903

3.  Rational perturbation of the fluorescence quantum yield in emission-tunable and predictable fluorophores (Seoul-Fluors) by a facile synthetic method involving C-H activation.

Authors:  Eun Joung Choi; Eunha Kim; Youngjun Lee; Ala Jo; Seung Bum Park
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-20       Impact factor: 15.336
  3 in total

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