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Literature DB >> 23337619

New tricks for old dogmas: optogenetic and designer receptor insights for Parkinson's disease.

Abstract

Optogenetics and novel designer receptors have revolutionized the way neuroscientists can interrogate neural circuits. These new tools are being rapidly applied to many facets of neuroscience including the study of Parkinson's disease circuitry and therapies. This review highlights how optogenetics and designer receptors can be applied in the study of Parkinsonian dysfunction to understand the mechanisms behind motor and non-motor symptoms. We discuss how these tools have recently advanced our understanding of basal ganglia function and outline how they can be applied in future to refine existing treatments and generate novel therapeutic strategies for Parkinson's disease. This article is part of a Special Issue entitled Optogenetics (7th BRES).

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Designer Drugs

Year: 2013 PMID： 23337619 PMCID： PMC3654066 DOI： 10.1016/j.brainres.2013.01.021

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

81 in total

1. Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release.

Authors: Dongdong Li; Karine Hérault; Ehud Y Isacoff; Martin Oheim; Nicole Ropert
Journal: J Physiol Date: 2012-01-04 Impact factor: 5.182

2. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.

Authors: Alexxai V Kravitz; Benjamin S Freeze; Philip R L Parker; Kenneth Kay; Myo T Thwin; Karl Deisseroth; Anatol C Kreitzer
Journal: Nature Date: 2010-07-07 Impact factor: 49.962

Review 3. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.

Authors: Gary Aston-Jones; Jonathan D Cohen
Journal: Annu Rev Neurosci Date: 2005 Impact factor: 12.449

Review 4. The Parkinson's complex: parkinsonism is just the tip of the iceberg.

Authors: J William Langston
Journal: Ann Neurol Date: 2006-04 Impact factor: 10.422

5. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.

Authors: Russell S Ray; Andrea E Corcoran; Rachael D Brust; Jun Chul Kim; George B Richerson; Eugene Nattie; Susan M Dymecki
Journal: Science Date: 2011-07-29 Impact factor: 47.728

6. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate.

Authors: Garret D Stuber; Thomas S Hnasko; Jonathan P Britt; Robert H Edwards; Antonello Bonci
Journal: J Neurosci Date: 2010-06-16 Impact factor: 6.167

7. Measurement of startle response, prepulse inhibition, and habituation.

Authors: M A Geyer; N R Swerdlow
Journal: Curr Protoc Neurosci Date: 2001-05

8. Optogenetics.

Authors: Karl Deisseroth
Journal: Nat Methods Date: 2010-12-20 Impact factor: 28.547

9. Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function.

Authors: Shengli Zhao; Jonathan T Ting; Hisham E Atallah; Li Qiu; Jie Tan; Bernd Gloss; George J Augustine; Karl Deisseroth; Minmin Luo; Ann M Graybiel; Guoping Feng
Journal: Nat Methods Date: 2011-09 Impact factor: 28.547

10. The pedunculopontine nucleus is related to visual hallucinations in Parkinson's disease: preliminary results of a voxel-based morphometry study.

Authors: J Janzen; D van 't Ent; A W Lemstra; H W Berendse; F Barkhof; E M J Foncke
Journal: J Neurol Date: 2011-06-30 Impact factor: 4.849

8 in total

New tricks for old dogmas: optogenetic and designer receptor insights for Parkinson's disease.

1. Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release.

2. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.

Review 3. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.

Review 4. The Parkinson's complex: parkinsonism is just the tip of the iceberg.

5. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.

6. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate.

7. Measurement of startle response, prepulse inhibition, and habituation.

8. Optogenetics.

9. Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function.

10. The pedunculopontine nucleus is related to visual hallucinations in Parkinson's disease: preliminary results of a voxel-based morphometry study.

Review 1. Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology.

2. Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson's disease.

3. Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures.

Review 4. Optogenetic Approaches to Target Specific Neural Circuits in Post-stroke Recovery.

Review 5. Treating Parkinson's disease in the 21st century: can stem cell transplantation compete?

Review 6. Nutritional and Nanotechnological Modulators of Microglia.

Review 7. New Targets and New Technologies in the Treatment of Parkinson's Disease: A Narrative Review.

Review 8. Neuroprotective Transcription Factors in Animal Models of Parkinson Disease.