OBJECTIVE: Granuloma-forming diseases such as sarcoidosis are associated with extrarenal synthesis of 1,25-dihydroxyvitamin D [1,25(OH)₂D]. We describe a case of extensive skin lesions associated with mineral oil injections in which we provide evidence for cutaneous granuloma synthesis of 1,25(OH)₂D in the pathogenesis of the patient's hypercalcemia. METHODS: Analysis of expression of the 25(OH)D-1a-hydroxylase (1-a OHase [CYP27b1]) was carried out by immunohistochemical analysis of involved skin. RESULTS: In involved skin, expression of CYP27b1 was found in the dermis, where it is not normally expressed. Successful management of hypercalcemia was achieved with glucocorticoids. CONCLUSIONS: Hypercalcemia associated with mineral oil induced skin lesions is likely driven by unregulated expression of CYP27b1 by inflammatory monocytes and macrophages infiltrating the dermis.
OBJECTIVE:Granuloma-forming diseases such as sarcoidosis are associated with extrarenal synthesis of 1,25-dihydroxyvitamin D [1,25(OH)₂D]. We describe a case of extensive skin lesions associated with mineral oil injections in which we provide evidence for cutaneous granuloma synthesis of 1,25(OH)₂D in the pathogenesis of the patient's hypercalcemia. METHODS: Analysis of expression of the 25(OH)D-1a-hydroxylase (1-a OHase [CYP27b1]) was carried out by immunohistochemical analysis of involved skin. RESULTS: In involved skin, expression of CYP27b1 was found in the dermis, where it is not normally expressed. Successful management of hypercalcemia was achieved with glucocorticoids. CONCLUSIONS:Hypercalcemia associated with mineral oil induced skin lesions is likely driven by unregulated expression of CYP27b1 by inflammatory monocytes and macrophages infiltrating the dermis.
Authors: Karin Lehner; Francesco Santarelli; Rudolf Vasold; Randolph Penning; Alexis Sidoroff; Burkhard König; Michael Landthaler; Wolfgang Bäumler Journal: PLoS One Date: 2014-03-26 Impact factor: 3.240
Authors: Andrea Sisti; Maria T Huayllani; David J Restrepo; Daniel Boczar; Oscar J Manrique; Peter N Broer; Shane A Shapiro; Antonio J Forte Journal: Acta Biomed Date: 2020-09-07
Authors: Nusha Fareen; Mohammad Umair Zafar; Zaka Ahmed; Mohammad A Hossain; Sushmitha P Diraviam; Sobaan Taj; Avais Masud Journal: Cureus Date: 2022-06-13