OBJECTIVE: Polymorphisms that reduce the activity of reduced folate carrier (RFC) and methylenetetrahydrofolate reductase (MTHFR) and double (2R2R) or triple (3R3R) 28-bp tandem repeats in the promoter region of thymidylate synthase (TS) have been associated with the risk of childhood acute leukemia (AL). A case-control genotyping study was conducted in Brazilian children with the aim of investigating RFC, MTHFR, and TS polymorphisms as risk factors. METHODS: The polymerase chain reaction-restriction fragment length polymorphism method was employed in 177 AL cases and 390 controls. RESULTS: The presence of the mutant 1298C, also RFC 80A, was linked to a decreased risk of developing acute lymphoid leukemia (ALL) (odds ratio (OR)=0.46, 95% confidence interval (CI)=0.30-071 and OR=0.51, 95% CI=0.28-0.0.93, respectively). CONCLUSIONS: The genotype 677 CT was associated with increased risk of developing ALL (OR=1.6, 95% CI=1.1-2.7). Further epidemiological study is needed to unravel the role of complex multiple gene-environment interactions in leukemogenesis.
OBJECTIVE: Polymorphisms that reduce the activity of reduced folate carrier (RFC) and methylenetetrahydrofolate reductase (MTHFR) and double (2R2R) or triple (3R3R) 28-bp tandem repeats in the promoter region of thymidylate synthase (TS) have been associated with the risk of childhood acute leukemia (AL). A case-control genotyping study was conducted in Brazilian children with the aim of investigating RFC, MTHFR, and TS polymorphisms as risk factors. METHODS: The polymerase chain reaction-restriction fragment length polymorphism method was employed in 177 AL cases and 390 controls. RESULTS: The presence of the mutant 1298C, also RFC 80A, was linked to a decreased risk of developing acute lymphoid leukemia (ALL) (odds ratio (OR)=0.46, 95% confidence interval (CI)=0.30-071 and OR=0.51, 95% CI=0.28-0.0.93, respectively). CONCLUSIONS: The genotype 677 CT was associated with increased risk of developing ALL (OR=1.6, 95% CI=1.1-2.7). Further epidemiological study is needed to unravel the role of complex multiple gene-environment interactions in leukemogenesis.
Authors: Hui Lv; Shao-Yan Hu; Zhi-Zuo Du; Zong Zhai; Lan Cao; Yi-Na Sun; Jun Lu; Jie Li; Hai-Long He; Yi-Huan Chai; Yi Wang Journal: Int J Clin Exp Pathol Date: 2018-03-01
Authors: M Forat-Yazdi; F Hosseini-Biouki; J Salehi; H Neamatzadeh; R Masoumi Dehshiri; Z Sadri; F Ghanizadeh; R Sheikhpour; H Zare-Zardini Journal: Iran J Ped Hematol Oncol Date: 2016-03-15