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Literature DB >> 23336060

Choline Molecular Imaging with Small-animal PET for Monitoring Tumor Cellular Response to Photodynamic Therapy of Cancer.

Baowei Fei¹, Hesheng Wang, Chunying Wu, Joseph Meyers, Liang-Yan Xue, Gregory Maclennan, Mark Schluchter.

Abstract

We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with (11)C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of (11)C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p < 0.001). However, for the control tumors, normalized choline uptake increased significantly (p < 0.001). PET imaging with (11)C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.

Entities: CellLine Chemical Disease Gene Species

Year: 2009 PMID： 23336060 PMCID： PMC3546344 DOI： 10.1117/12.812129

Source DB: PubMed Journal: Proc SPIE Int Soc Opt Eng ISSN： 0277-786X

16 in total

1. Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat.

Authors: John E George; Yusra Ahmad; Davood Varghai; Xiaolin Li; Jeffrey Berlin; David Jackowe; Marc Jungermann; Michael S Wolfe; Lothar Lilge; Ali Totonchi; Rachel L Morris; Allyn Peterson; W David Lust; Malcolm E Kenney; Charles L Hoppel; Jiayang Sun; Nancy L Oleinick; David Dean
Journal: Lasers Surg Med Date: 2005-06 Impact factor: 4.025

2. Deformable and rigid registration of MRI and microPET images for photodynamic therapy of cancer in mice.

Authors: Baowei Fei; Hesheng Wang; Raymond F Muzic; Chris Flask; David L Wilson; Jeffrey L Duerk; Denise K Feyes; Nancy L Oleinick
Journal: Med Phys Date: 2006-03 Impact factor: 4.071

3. Dynamic imaging of transient metabolic processes by small-animal PET for the evaluation of photosensitizers in photodynamic therapy of cancer.

Authors: Véronique Bérard; Jacques A Rousseau; Jules Cadorette; Laurent Hubert; M'hamed Bentourkia; Johan E van Lier; Roger Lecomte
Journal: J Nucl Med Date: 2006-07 Impact factor: 10.057

Review 4. Choline metabolism in cancer: implications for diagnosis and therapy.

Authors: Kristine Glunde; Michael A Jacobs; Zaver M Bhujwalla
Journal: Expert Rev Mol Diagn Date: 2006-11 Impact factor: 5.225

5. Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.

Authors: T R DeGrado; R E Coleman; S Wang; S W Baldwin; M D Orr; C N Robertson; T J Polascik; D T Price
Journal: Cancer Res Date: 2001-01-01 Impact factor: 12.701

6. Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.

Authors: C M Whitacre; D K Feyes; T Satoh; J Grossmann; J W Mulvihill; H Mukhtar; N L Oleinick
Journal: Clin Cancer Res Date: 2000-05 Impact factor: 12.531

7. Development of (18)F-fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging.

Authors: Toshihiko Hara; Noboru Kosaka; Hiroichi Kishi
Journal: J Nucl Med Date: 2002-02 Impact factor: 10.057

8. Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

Authors: M E Kaighn; K S Narayan; Y Ohnuki; J F Lechner; L W Jones
Journal: Invest Urol Date: 1979-07

Review 9. Photodynamic therapy with the phthalocyanine photosensitizer Pc 4: the case experience with preclinical mechanistic and early clinical-translational studies.

Authors: Janine D Miller; Elma D Baron; Heather Scull; Andrew Hsia; Jeffrey C Berlin; Thomas McCormick; Valdir Colussi; Malcolm E Kenney; Kevin D Cooper; Nancy L Oleinick
Journal: Toxicol Appl Pharmacol Date: 2007-02-15 Impact factor: 4.219