Literature DB >> 23335736

Involvement of efflux pumps in the resistance to peptidoglycan synthesis inhibitors in Mycobacterium tuberculosis.

Neela Dinesh1, Sreevalli Sharma, Meenakshi Balganesh.   

Abstract

We evaluated the contributions of Mycobacterium tuberculosis efflux pumps towards intrinsic resistance to different classes of peptidoglycan synthesis inhibitors (PSI). Our study indicates that the efflux pump knockout strains are more susceptible to PSI than the wild type. Vancomycin and ceftriaxone exhibited up to 3 log increased kill on efflux pump mutants compared to the wild-type strain, strongly suggesting an important role for efflux pumps in the intrinsic resistance of M. tuberculosis to PSI.

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Year:  2013        PMID： 23335736      PMCID： PMC3623302          DOI： 10.1128/AAC.01957-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

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4.  Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.

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Journal:  Biochemistry       Date:  2010-05-04       Impact factor: 3.162

5.  Imipenem for treatment of tuberculosis in mice and humans.

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7.  Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs.

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Review 8.  Resistance to beta-lactam antibiotics.

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Review 3.  Energy metabolism and drug efflux in Mycobacterium tuberculosis.

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Review 6.  Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development.

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9.  Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics.

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Journal:  EBioMedicine       Date:  2016-06-01       Impact factor: 8.143

10.  Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes.

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